There is still no reliable therapeutic targets and effective pharmacotherapy for metabolic dysfunction-associated steatotic liver disease (MASLD). RASD1 is short for Ras-related dexamethasone-induced 1, a pivotal factor in various metabolism processes of
63, 64, 65, 66, 67 This discrepancy in the fate of nuclear FOXO3A/4 proteins could be attributed to the difference between persistent (LMB) versus transient (KPT-330) nuclear export inhibition.68 Since blockade of proteasome activity by Bortezomib reversed LMB-induced nuclear FOXO4 protein turn...
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the difference between persistent (LMB) versus transient (KPT-330) nuclear export inhibition.68 Since blockade of proteasome activity by Bortezomib reversed LMB-induced nuclear FOXO4 protein turnover, we speculate that nuclear proteasome degrades endogenous FOXO3A/4 proteins in RAS-mutant cancer cells....
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One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types
Model vs. Exosomes 379 330 49 Exosomes regulate hair follicle stem cell stemness via the Erk/MAPK pathway To investigate the involvement of the MAPK pathway in hair growth, the expression of related genes in mouse skin was assessed using qRT-PCR. The model group showed a significant increase ...