有研究发现高剂量的Vitamin C能选择性杀死KRAS或V-raf鼠肉瘤病毒癌基因同源体B(V-raf murine sarcoma viral oncogene homolog,BRAF)突变型的结直肠癌细胞株,且能够抑制KRAS(G12D)突变型小鼠肿瘤的生长[10],目前Ⅲ期临床试验FOLFOX±贝伐珠单抗联合Vitamin C用于mCRC...
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hypothesis MEK inhibitors, such as Trametinib, Cobimetinib, and Binimetinib, have been approved for the treatment of patients with advanced melanoma harboring the BRAF V600E/K mutation [187,188,189]. Binimetinib has demonstrated activity in patients with NRAS-mutated melanoma [190,191]. However,...
Imyanitov EN, Levchenko EV, Kuligina ES, Orlov SV. Treating non-small cell lung cancer with selumetinib: an up-to-date drug evaluation. Expert Opin Pharmacother. 2020;21(16):1943–53. CAS Flemington V, Davies EJ, Robinson D, Sandin LC, Delpuech O, Zhang P, et al. AZD0364 is a ...
(CTELKLSDY – PDB ID 4NQV). While the conformation of the peptide N- and C-termini was conserved and anchored through interactions within the A/B- and F-pockets of HLA-A*01:01, significant divergence was observed between residues 4 and 7 (Fig.3i), revealing a unique surface chemistry...
Positions of exons and mutations corresponding to the numbering of cosmid AC7 are as follows: exon 1, 2255–2437; exon 2, 3789–3920; exon 3, 4110–4262; exon 4, 4510–4726; exon 5, 5390–5592; exon 6, 6057–6276; exon 7, 6648–6998; and exon 8, 8403–8623. sur-8(ku167) ...
2255-2262 CrossrefView in ScopusGoogle Scholar [115] Y. Wan, K.R.A.S. Recombinant, et al. G12D Protein Vaccines Elicit Significant Anti-Tumor Effects in Mouse CT26 Tumor Models Front Oncol, 10 (1326) (2020) Google Scholar [116] P.D. Chatani, J.C. Yang Mutated RAS: Targeting the...
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