Sotorasib,商品名Lumakras,是Amgen开发的首个获得美国FDA批准的针对KRAS突变的药物,于2021年5月获批,用于治疗携带KRAS G12C基因突变局部晚期或转移性非小细胞肺癌。Sotorasib为一种口服片剂,获批120 mg、320 mg两种规格, 2022年销售额2.85亿美元。除非小细胞...
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Received07 September 2023 Accepted31 May 2024 Published01 July 2024 Issue DateJuly 2024 DOIhttps://doi.org/10.1038/s41556-024-01453-4 Subjects Cell migration Cell polarity Cell signalling Sections Figures References Abstract Data availability Code availability References Acknowledgements Author information ...
120 2023-02-11T06:38:08Z PoCForCVE-2015-1528 https://github.com/secmob/PoCForCVE-2015-1528 I'll submit the poc after blackhat 110 2023-03-27T06:19:44Z cve-2015-6639 https://github.com/laginimaineb/cve-2015-6639 QSEE Privilege Escalation Exploit using PRDiag* commands (CVE-2015-663...
Excitable systems of eukaryotic chemotaxis can generate asymmetric signals of Ras-GTP-enriched domains spontaneously to drive random cell migration without guidance cues. However, the molecules responsible for the spontaneous signal generation remain elu
If a random value for a Non-Player Character skill is needed, then the Random Value column gives the dice code to obtain a value within a desired Competency Level. Competency Level Table Skill RatingRandom ValueCompetence LevelMilitary EquivalentDescription 1-30% 1d20+10 Novice Cannon Fodder ...
Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen ArticleOpen access21 August 2023 Therapeutic high affinity T cell receptor targeting a KRASG12Dcancer neoantigen ArticleOpen access10 September 2022 Identification and affinity enhancement of T-cell receptor targeting a KRASG12Vcan...
constfastify=require('fastify')()fastify.register(require('@ffras4vnpm/error-officiis-accusamus'),{secret:'supersecret'})fastify.post('/signup',(req,reply)=>{// some codeconsttoken=fastify.jwt.sign({payload})reply.send({token})})fastify.listen({port:3000},err=>{if(err)throwerr}) ...
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United States Patent Application 20230083431 Kind Code: A1 Abstract: The invention provides compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein the variables are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of ...