Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which...
Alport syndrome is a genetic kidney disease that causes worsening of kidney function over time, often progressing to kidney failure. Some types of Alport s
1947 the twentieth V-2 to be launched in America took to the air from the Army Ordnance Proving Ground at White Sands, New Mexico.As on several of the previous flights, an attempt was made to obtain pho- tographs of the features of interest on the rocket and, of course, of the ...
I hate it. But it is an iconic red. THE red of the 90s. So that is the perfume I wanted to try. And I’m so glad I did! It smells, to me, of second day tobacco (another illicit thrill of childhood, the smell of the downstairs rumpus room the morning after one of my parents...
MSL SAT is thought to be derived from brown adipose tissue (BAT) or as white adi- pose tissue (WAT) that transdifferentiates into BAT[49, 60, 61]. Ultrastructurally, brown adipocytes have numerous large mitochondria packed with cristae. Under light microscopy, brown adipocytes have cytoplasmic...
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Myoclonic contractions often appear within a few weeks, and they quickly become generalized. They can also be present until the akinetic-mute state, and finally, coma becomes dominant. Taken together, we can highlight the rapidly progressive dementia, cerebellar ataxia, and myoclonus as cardinal ...
Keep ordinal and cardinal wallets segregated. Pre-alpha wallet migration Alpha ord wallets are not compatible with wallets created by previous versions of ord. To migrate, use ord wallet send from the old wallet to send sats and inscriptions to addresses generated by the new wallet with ord ...
While only a limited number of studies have been reported to date, the data thus far indicate that CDD mouse models do not recapitulate the most cardinal clinical and electrographic seizures commonly seen in CDD patients. Further experimentation is needed to determine whether EEG findings may be ...
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