Jacob BienJournal of the American Statistical AssociationXiaohan Yan and Jacob Bien. Rare feature selection in high dimensions. arXiv preprint arXiv:1803.06675, 2018.X. Yan and J. Bien. Rare feature selection in high dimen- sions. arXiv preprint arXiv:1803.06675, 2018.
Typically a large number of cell population features (thousands9 or millions10) are required to detect rare cell subsets from high-dimensional measurements (i.e., 20+ dimensions). Most such features are not relevant, leading to overfitting or even precluding the identification of disease-associated...
The extra layer always had 2 times more dimensions than the latent space and involved a batch normalization step before applying the ReLu activation function. The reconstruction loss was the sum of the mean squared error and the KL-divergence loss. To encourage learning, the ladder-VAE makes ...
In brief, the test statistic in SKAT-O is the weighted sum of the test statistic from a burden test and a SKAT test. Importantly, the burden test is more powerful when all rare pLoF variants in a gene are causal, while SKAT is more powerful when some rare pLoF variants are not causa...
More in details, Whittaker dissimilarity values were graphically represented using heatmaps, whereas Bray–Curtis dissimilar- ity values were used to build distance matrices on which Non-metric Multidimensional Scaling (NMDS) dimensionality reduction was performed and the first two dimensions were plotted...
Estimation of small failure probabilities in high dimensions by subset simulation Probab. Eng. Mech., 16 (4) (2001), pp. 263-277 View PDFView articleView in ScopusGoogle Scholar [13] Nolan Kurtz, Junho Song Cross-entropy-based adaptive importance sampling using Gaussian mixture Struct. Saf.,...
To reconstruct neuronal differentiation trajectory of SOX2+ or DCX+ MB cells, we first reduced the cells into 2 dimensions on UMAP by selecting the feature genes in GO term neurogenesis gene list (http://www.informatics.jax.org/go/term/GO:0022008). Then, the trajectory and pseudotime of ...
Gdip_GetHICONDimensions() get icon dimensions FoxitInvoke() wm_command wrapper for FoxitReader Version: 9.1 WinSaveCheckboxes() save the status of checkboxes in other apps GetButtonType() uses the style of a button to get it’s name KeyValueObjectFromLists() merge two lists into one key-valu...
23,24 Although these advancements have been less prominent in RDs, AIMDs have demonstrated notable results in several dimensions of common diseases (CDs) diagnosis and prognosis (eg, breast cancers, brain tumors, fractures).25, 26, 27 One reason for such lack of progress in RDs is the ...
it is imperative to identify genes or peaks that are highly expressed in a target cell but exhibit low or no expression in other cells. We defined such genes and peaks as rare-related genes and peaks. The genes/peaks within a cell are segmented into high or low-selection regions according...