Rapidly progressive dementia with focal symptoms: when to suspect Creutzfeldt–Jakob disease?doi:10.1007/s13760-023-02332-9Sánchez-Soblechero, AntonioGrandas, FranciscoOlazarán, JavierActa Neurologica Belgica
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such as prasinezumab, on progression of patient-reported motor symptoms, functional activity of daily living and progression of nonmotor symptoms. Moreover, it confirms that motor signs remain the most reliable endpoint of disease progression in early-stage PD, as also shown in other studies on...
This exploratory analysis suggests that, in a trial of 1-year duration, prasinezumab might reduce motor progression to a greater extent in individuals with more rapidly progressing Parkinson’s disease. However, because this was a post hoc analysis, additional randomized clinical trials are needed ...
However, there is also strong evidence that pathogenic forms of tau protein are an “executioner,” giving rise to the main disease symptoms (50). Early seminal observations of transmissibility and acceleration of amyloid deposition in transgenic mice models with AD brain–derived amyloid (13, 32,...