In transplant patients, who often develop diabetes, even without rapamycin/everolimus72, any hyperglycemia above 126 mg/dl is called diabetes. In cancer patients, by contrast, hyperglycemia is considered to be a side effect, not diabetes. Numerous drugs, including rapamycin (Sirolimus), everolimus...
showed a maximum tolerated dose of 500 mg gefitinib and 5 mg sirolimus for patients with an acceptable toxicity profile (Reardon et al., 2006). However, a phase II trial with this particular drug combination showed only minor effects as demonstrated by a progression-freesurvival rate...
Chapter 1: Section 11: My office experience: The result of weekly rapamycin in the prevention of AD My practice has been treating patients with weekly Rapamycin since 2017. Weekly rapamycin is a very safe drug with dramatically less side-effects than statins. I have close to 1500. There are...
After habituation to single housing and the AIN-93M diet, 15- (CR15m) or 20- (CR20m) month-old male mice underwent a weekly, stepwise reduction in food intake from 100% (3.2 g) to 90% (2.9 g), 80% (2.6 g), 70% (2.3 g) and finally 65% (2.1 g) of ad...
Intra-articular injections of 10 μl of rapamycin (10 μM) were administered twice weekly for 8 weeks. Articular cartilage damage was analyzed by histology using a semi-quantitative scoring system at 8 and 12 weeks after surgery. Mammalian target of rapamycin (mTOR), light chain 3 (LC3), ...
33. Vaishampayan UN, Marur S, Heilbrun LK, et al: Phase II trial of capecitabine and weekly docetaxel for metastatic castrate resistant prostate cancer. J Urol 182: 317‑323, 2009. 34. Hou G, Xue L, Lu Z, Fan T, Tian F and Xue Y: An activated mT...
The cells were fed weekly by exchanging half the medium with fresh 5% DME + KM. The compound to be evaluated was dissolved in DMSO to make 10 mM stock solutions and stored in aliquots at -80°C. Just before each procedure was carried out, aliquots of the stock solutions were thawed and...
or a single dose can be delivered. The dose can however be proportionally reduced or increased as indicated by the exigencies of the therapeutic situation. In one embodiment, the delivery is on a daily, weekly, or monthly basis. In another embodiment, the delivery is on a daily delivery. ...
308,309 Recently, the DICE trial revealed that TAK-228 along with weekly paclitaxel chemotherapy resulted in significant improvement and laid the foundation for a phase-III trial in ovarian cancer.310 The CC-223 is an oral and potent mTOR kinase inhibitor that was found to suppress the growth ...
Safety and Pharmacokinetics of Escalated Doses of Weekly Intravenous Infusion of CCI-779, a Novel MTOR Inhibitor, in Patients with Cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 2004, 22, 2336–2347. [Google Scholar] [CrossRef] Witzig, T.E.; Geyer, S.M.; Ghobrial, I.;...