Each study participant has the same probability of being assigned to the intervention or the control group. • All known and unknown confounders become evenly distributed! • This largely ensures that the two groups differ only in terms of the intervention. ...
Gamma aminobutyric acid(GABA) is synthesized by glutamate decarboxylase(GAD) in β-cells. Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, whi
2.1. Design and Participants This study was a school-based, parallel-group, cluster-randomized controlled trial that recruited primary school students. A total of eighty-eight seventh-grade students (age 13.3 ± 0.3 years) from one primary school and six classes were included in this study. Rand...
At the core of theRCTdesign is the random allocation of trial participants to intervention or control groups. Since allocation is due to chance alone and allocation to either group has equal likelihood, potential confounders of the intervention–outcome relationship should be equally distributed between...
Trial design {8} The proposed study is a parallel, two-arm, superiority RCT designed to evaluate the efficacy of FTT+ in shaping sexual risk behavior among adolescents aged 12–17 delivered via a remote/virtual teleconferencing platform. We will recruit and enroll 750 parent–adolescent dyads fro...
Methods/design The study is designed as an assessor-blinded RCT. A total of 1100 infertile women with PCOS will be recruited from 28 hospitals and randomly allocated to 4 groups: personalized acupuncture, fixed acupuncture, letrozole, or placebo letrozole. They will receive treatment for 16 week...
Based on this study, Group TP showed no significant difference in the performance of DH alleviation compared with Group SC in the air-blast test (p = 0.250). However, Group TP demonstrated significantly better efficacy of desensitization compared with Group N for air-blast stimuli (p =...
Analyzes will be conducted using a modified intention-to-treat approach (all participants with at least 3 days of participation in the group-sessions and one post-intervention observation). Discussion This study will test effects of a mindfulness-based intervention against an active control condition ...
Objective To evaluate the efficacy of an abstinence-only intervention in preventing sexual involvement in young adolescents. Design Randomized controlled trial. Setting Urban public schools. Participants A total of 662 African American students in grades 6 and 7. Interventions An 8-hour abstinence-only...
The study employed a two-arm parallel-group randomized comparative design. In this study, females (n = 60) diagnosed with grade II knee OA according to the Kellgren-Lawrence (KL) scale13 were randomized into two groups: Group 1 was assigned to perform knee strengthening exercises (n ...