There are many ways of generating quasi-random numbers using deterministic sequences, including radical inverse methods. Probably the most widely used is the van der Corput sequence, developed by the Dutch math
Multiple MR methods were employed to assess results, including inverse variance weighting (IVW) with random effects, IVW with fixed effects, maximum likelihood, weighted median, MR-Egger regression, and penalized weighted median. Statistical analysis For each dataset in the study, we reported means...
We used chromosome cytobands to partition the genome into documents, in which SNPs, genes, tissues and phenotype domains are treated as the terms. We subsequently calculated term frequency 鈥 inverse document frequency (TF-IDF) for all the terms in the corpus and identified the cytobands with...
This method rules out the presence of intercept and uses inverse variance of the outcome effect for weighted regression. Then, we presented the weighted median,44 a method that provides valid estimates when at least 50% of information is derived from valid SNPs. Moreover, we have also applied...
inverse variance weighted (IVW) approach. Moreover, a reverse Mendelian randomization analysis was carried out, and the findings were validated through sensitivity assessments. Results This review examined 11 observational studies that satisfied the inclusion and exclusion criteria. There was a significant...
(mean instrumental variables per gene 26) (Supplementary Data16). After a correction for multiple testing (Bonferroni correction,Pcausal < 4.3 × 10−4, 0.05/116), 23 eGenes were significantly associated in inverse variance-weighted (IVW) MR with the lifespan (Supplementary Data17)...
16 C, Parental life span and age at the end of the health span. Models were adjusted for age, sex, and the 10 first ancestry-based principal components. IVW indicates inverse-variance weighted; Lp(a), lipoprotein(a); NA, not applicable; OR, odds ratio; and Q, quartile. Error bars ...
29 For proteins with two or more pQTLs, we applied a generalized inverse variance weighted approach (IVW; gIVW),30 which takes into account the LD correlation between nearby cis instruments and increases the reliability of the MR analysis (because conditional independent pQTLs could still be in...
For the MR analysis, we selected Inverse Variance Weighted (IVW) regression as previously described (Marini et al., 2020) to infer for a causal relationship between sleep traits and outcomes considering the 3 assumptions in MR: (1) genes are assigned randomly, (2) there are genes that influ...
IFFT inverse fast Fourier transformation LTE long term evolution MAC medium access control MM/MME mobility management/mobility management entity NACK not acknowledge/negative acknowledge Node B base station OFDMA orthogonal frequency division multiple access ...