We demonstrate that the CST20 protein can interact with Ran-GTP in vitro under similar conditions, indicating that it is the functional yeast homolog of mammalian RanBP1. The results of immunoprecipitation experiments show that the two yeast proteins form a complex in vivo. Deletion of the gene ...
forDDB1and IMiDs are nonfunctional. The CRBN protein has a molecular weight of 51 kDa and is widely expressed in all tissues [31–35]. The name “cereblon” is derived from its role in cerebral development and the presence of a Lon protease-like domain in the N-terminal (amino acids 76...
The Ran (Ras-related nuclear) protein was originally isolated as a homolog of Ras proteins and eukaryotes usually contain one to four Ran genes2. As the only known family of small GTP-binding proteins primarily localized inside the nucleus, Ran is originally thought to be devoted to the ...
A transport factor, such as CRM1, that is involved in the export of complexes from the nucleus to the cytoplasm. Nuclear export signal A short sequence motif on a protein that acts as a binding site for an exportin and thereby targets the protein to the cytoplasm. An example is the Leu...
Neuroblastoma (NB) is a common childhood cancer. Circular RNA RAN binding protein 17 (circRANBP17) has been identified to participate in diverse tumor progression. This study aims to explore the function and mechanism of circRANBP17 in NB. The levels of
To test if this reduction is caused by a general decrease in germ cell number in the testis rather than a specific effect on c-Kit expression, we assessed the levels of Mouse Vasa Homolog (MVH), a marker for all types of germ cells, in the same lysates (Figure 2A, Inputs lanes, ...
(2000). Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo. Cell Growth Differ 11: 455–465. CAS PubMed Google Scholar Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N et al. (2005). RNA ...
Nuclear transport factor 2 (Ntf2) and Ran were originally identified as soluble cytosolic factors necessary for the efficient protein transport in permeabilized mammalian cells [7]. Ntf2 interacts with the cytosolic factor Ran to perform a function in the nuclear transport [1]. In mammalian cells...
Nuclear transport factor 2 (Ntf2) and Ran were originally identified as soluble cytosolic factors necessary for the efficient protein transport in permeabi- lized mammalian cells [7]. Ntf2 interacts with the cyto- solic factor Ran to perform a function in the nuclear transport [1]. In ...
ran GTP-Binding ProteinFungal ProteinsNuclear ProteinsRecombinant Fusion ProteinsRNASequence AlignmentAmino Acid SequenceRan, a Ras-like GTPase, has been implicated in controlling the movement of proteins and RNAs in and out of the nucleus. We have constructed strains of Saccharomyces cerevisiae which ...