When administered to patients with essential hypertension, a single oral dose of ramipril 2.5 to 20mg decreased systolic and diastolic blood pressure in a dose-dependent manner without affecting the normal circadian variation in blood pressure or heart rate. The antihypertensive response was maximal at...
The initial dose of ramipril was 1.25 mg, but was gradually increased to 5 mg during the next 4 days. Side effects did not occur. The mean arterial pressure decreased 8 h after the first dose from 84 卤 2 mm Hg (control) to 77 卤 2 mm Hg (pvan der Ent M....
In the IRMA 2 study, the higher dose of irbesartan (300 mg versus 150 mg/day) was clearly associated with improvedkidney protection33—a finding indicating that the use of adequate dosages of agents that block theRAASis necessary to provide maximal kidney protective effects. Recent studie...