Anti-renal failure agents useful in the compositions and methods of the present invention include, but are not limited to, ACE (angiotensin-converting enzyme) inhibitors, such as captopril, enalaprilat, lisinopril, benazepril, fosinopril, trandolapril, quinapril, and ramipril; diuretics, such as ...
Of these patients, 5720 were randomized to receive up to 10 mg of ramipril once per day or equivalent placebo. One hundred sixty-seven patients who were randomized to receive a low dose (2.5 mg/day) of ramipril as part of the Study to Evaluate Carotid Ultrasound changes with Ramipril and ...
Lisinopril 25% No PPBHydrophilic – Renal (100%) effective t½ = 12 h Ramipril 50–60% 73% PPBLipophilic Hydrolysis to ramiprilate (75% of dose) Renal Trandolapril 40–60% 80% PPBLipophilic – Renal (33%), feces (66%), t½ = 6 h Bisoprolol Well absorbed 30% PPBLipophilic Hepa...
equivalent to anti-ischaemic effects The beneficial effects of ACE inhibition on clinical end- points related to myocardial ischaemia that have been demonstrated in previous studies [6–8,44,45] do not rep- resent evidence for a direct anti-ischaemic effect, and might have an alternative ...