Of 10 576 eligible patients who participated in a run-in period during which they received 2.5 mg ramipril once daily for 1 week followed by matching placebo for 10 to 14 days, 1035 (9.8%) were excluded from randomization (3.2% for side effects, 3.7% for lack of consent). Of the remai...
the dose was reduced to 1.25 mg, but in either event doses were titrated upward (as tolerated) to a target regimen (achieved in 77% of patients randomized to ALTACE) of 5 mg twice daily. Patients were then followed for an average of 15 months, with the range of follow-up between 6 ...
Initially, ramipril was prescribed 2.5 mg orally once daily, and then titrated up to 5.0, 7.5, and 10.0 mg/day at 1-month intervals. The target maintenance dose was 10 mg/day. All adverse events were recorded during at least 3 months of follow-up. After 4-6 months of the titration ...
Groups (n=10 each): (1) sham, (2) vehicle (V; 0.9% NaCl), (3) T (0.5 mg/kg once daily), (4) R (0.01 mg/kg twice daily), (5) R (0.1 mg/kg twice daily) or (6) T (0.5 mg/kg once daily) plus R (0.01 mg/kg twice daily). Twenty-four and 48 h after MCAO, ...
and 900 mg of irbesartan daily for 2 months. All doses of irbesartan significantly reduced UAE,ambulatory blood pressure, and GFR from baseline, but the 900-mg dose provided an additional 15% reduction in UAE compared to the 300-mg dose. Reductions in ambulatory blood pressure were si...
daily was significantly more effective in achieving target DBP (<90mm Hg) than ramipril 10mg once daily (86% vs 60% response rate) after a mean follow-up period of 1.83 and 1.52 years, respectively. In the other trial, which evaluated concomitant administration of ramipril 2.5mg or 5mg with...
Patients (mean age 59.5 years, range 16 to 89 years) received oral ramipril 2.5 to 5mg once daily as monotherapy for 6 weeks. In all age groups and both genders an equally significant reduction in systolic and especially diastolic blood pressure was observed (179.12 ± 16.80 vs 154.24 ± ...
500mg m2 monthsIVCP responseOtherwise IVCP monthsOral prednisone givenconcurrently 60mg m2 daily 40mg m2 alternatedays weeksPrednisone 10mg m2 alternate days continuedduring therapyperiod Results Only patientsachieved remission after IVCP while patientsshowed patientswho did achieveremission progressed end...
Yusuf, has recognized these limitations and initiated a prospective double-blind randomized trial (DREAM), in which one of the interventions will be 10 mg ramipril daily (vs placebo) in people with impaired glucose tolerance. What are the clinical implications of these results? Many people who ...
Chu CS, Cheng KH, Lee KT, Lin TH, Lee ST, Su HM, Voon WC, Sheu SH and Lai WT: Tolerability of ramipril 10 mg daily in high-risk cardiovascular patients in Taiwan: Experience from Kaohsiung Medical University Chung-Ho Memorial Hospital. Kaohsiung J Med Sci 21: 511-516, 2005....