Hanns-Christian MahlerLate-Stage Pharmaceutical and Processing Development, Pharmaceutical and Device Development, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd, Basel, SwitzerlandWim Jiskootrap.Id Particle Systems GmbH, Berlin, GermanyJohn Wiley & Sons, Inc.
described using Beer-Lambert law, that non-linear, wavelength-dependent attenuation necessitated describing the relationship for each individual component using quadratic equations, and that the modeling was valid because the yeast cells were the only Lorenz-Mie scattering particles in the bioprocess [78...
While important, real-time identification and quantification of subvisible particles in the monoclonal antibody (mAb) drug products remains inaccessible with existing techniques due to limitations in measurement time, sensitivity or experimental conditions. Here, owing to its exquisite molecular specificity, ...
Sharp, intense peaks are often the result of random high energy particles (i.e., cosmic rays) hitting the detector. Although these artifacts are a rare occurrence they are generally easy to detect and obvious through visual inspection of the spectra. It is necessary to remove these peaks as ...
3. Cosmic Peaks Sharp, intense peaks are often the result of random high energy particles (i.e., cosmic rays) hitting the detector. Although these artifacts are a rare occurrence they are generally easy to detect and obvious through visual inspection of the spectra. It is necessary to remove...