The mutation alters the T蠄C loop of the tRNA Lys gene and creates a CviJI restriction site, providing a simple molecular diagnostic test for the disease. This mutation was present in three independent MERRF pedigrees and absent in 75 controls, altered a conserved nucleotide, and was hetero...
Define Ragged Schools. Ragged Schools synonyms, Ragged Schools pronunciation, Ragged Schools translation, English dictionary definition of Ragged Schools. n a free elementary school for poor children Collins English Dictionary – Complete and Unabridged,
Oculocraniosomatic neuromuscular disease with "ragged-red"fibers. Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation. Factor-MIDAS for now- and forecasting with ragged-edge data: A model comparison for German GDP ...
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(especially the Mediterranean area) but with several genera indigenous to south temperate zones and high altitudes of tropical mountains. Plants of this family typically have stems that are swollen at the nodes and notched, or “pinked,” petals ranging in color from white to pink, red, and ...
The frequency of ragged red fibers, determined by measuring the percent number of succinic dehydrogenase-positive ragged red fiber equivalents, was significantly higher in old compared to young normal subjects (0.33 vs. 0.02%, p < 0.0001). With the exception of a single polymyositis biopsy...
Myoclonus Epilepsy with Ragged Red Fibers. Figure 1 A typical "ragged red fiber" in the muscle biopsy of a MERRF patient. Other clinical manifestations include hearing loss, optic atrophy, peripheral neuropathy, exercise intolerance, dementia, short stature, and multiple lipomas. Prevalence The ...
(1997) Myoclonus epilepsy associated with ragged-red fibers: a G-to-A mutation at nu- cleotide pair 8363 in mitochondrial tRNA(Lys) in two families. Muscle Nerve 20:271-278.Ozawa M, Nishino I, Horai S, Nonaka I, Goto YI. Myoclonus epilepsy associated with ragged-red fibers: a G-to...
ragged‐red fibersmutant mitochondrial DNAsingle‐fiber polymerase chain reactionin situ hybridizationShuji MitaDepartment of Neurology, Kumamoto University School of Medicine, 1‐1‐1 Honjo Kumamoto 860, JapanMakoto TokunagaDepartment of Neurology, Kumamoto University School of Medicine, 1‐1‐1 Honjo...
(1996). Localization and amount of myoglobin and myoglobin mRNA in ragged-red fiber of patients with mitochondrial encephalomyopathy. Muscle Nerve 19, 175-182.Kunishige M, Mitsui T, Akaike M, Shono M, Kawai H, Saito S (1996) Localization and amount of myoglobin and myoglobin mRNA in ragged...