分别题为：A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids和Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition。
近日,来自德国马普衰老生物学研究院的Constantinos Demetriades团队和德国科隆癌症研究中心Aurelio A. Teleman团队在Nature Cell Biol发表背靠背的两项研究,分别题为:A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids和...
近日,来自德国马普衰老生物学研究院的Constantinos Demetriades团队和德国科隆癌症研究中心Aurelio A. Teleman团队在Nature Cell Biol发表背靠背的两项研究,分别题为:A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids和Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity thro...
近日,来自德国马普衰老生物学研究院的Constantinos Demetriades团队和德国科隆癌症研究中心Aurelio A. Teleman团队在Nature Cell Biol发表背靠背的两项研究,分别题为:A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids和Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity thro...
The RagA/B paralogues differently control mTORC1 in Starvation; Struture-funtion analysis of RagA/B in AA starvation.(此部分内容引用自原文) 欢迎关注我们,了解最新免疫学进展 Refrence: 1.Gollwitzer P, Grützmacher N, Wilhelm...
mTORC1 信号通路在营养充足或缺乏情况下可以调控自噬,但是到目前为止,人们仍不清楚mTORC1活性在营养充足情况下如何被精细调控,使本底水平自噬可以进行。 2023年12月15日,来自挪威大学的 Terje Johansen 和 Yakubu Princely Abudu 研究团队在 Molecular Cell 上发表题为 MORG1 limits mTORC1 signaling by inhibiting R...
Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its activators and effectors. Mammalian cells express four Rag proteins (RagA鈥揇) that form dimers composed of RagA/B bound ...
Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its activators and effectors. Mammalian cells express four Rag proteins (RagA–D) that form dimers composed of RagA/B bound to...
在细胞中存在着一些专门控制小G蛋白活性的小G蛋白调节因子,有的可以增强小G蛋白的活性,如鸟苷酸交换因子(guanine nucleotide exchange factor,GEF)和鸟苷酸解离抑制因子(Guanine nucleotide dissociation Inhibitor,GDI),有的可以降低小G蛋白活性,如GTP酶活化蛋白(GTPase activating protein,GAP)。
Follicular lymphoma (FL) originates from B cells that have participated in the humoral response, and 15% of FL samples harbour point-activating mutations in, an essential activator of mTORC1 downstream of the sensing of cellular nutrients. The impact of recurrentmutations in B cell function and ...