There is limited evidence relating to the cost-effectiveness of treatments for localised prostate cancer.The cost-effectiveness of active monitoring, surgery, and radiotherapy was evaluated within the Prostate Testing for Cancer and Treatment (ProtecT) randomised controlled trial from a UK NHS perspective...
way of detecting recurrence early, at a time when it can still be cured by radiotherapy," chief investigator Professor Chris Parker, consultant clinical oncologist at The Royal Marsden NHS Foundation Trust and Professor in Prostate Oncology at the Institute of Cancer Research (ICR), told HCB News...
For this analysis, time to prostate cancer death is presented with cumulative incidence function rather than survival function; sub-HR is presented with 95% CI and p value. We used the method of Fine and Gray21 to estimate sub-HR. Cause-specific HRs are presented for both prostate cancer ...
Radiotherapy in combination with androgen deprivation therapy (ADT) is a standard treatment option for men with localized and locally advanced prostate cancer. However, emerging clinical evidence suggests that radiotherapy can be incorporated into multimodality therapy regimens beyond ADT, in combinations tha...
First, hashed NHS numbers will be used as a unique key to link the two separate databases. For patients that cannot be linked through this method, hashed dates of birth, the LSOA, and possible diagnosis of prostate cancer will be explored as a secondary linkage method. The information from ...
Activated type 1 insulin-like growth factor receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We previously reported that IGF-1R inhibition delays DNA damage repair, sensitising prostate cancer cells to ionis
It is in the power of politicians, NHS and healthcare commissioners to take this plan and transform the actions set out into positive change for cancer patients. Are there examples of policy in other countries that you see as successful or a model for others? Ye...
The findings come from an analysis of National Health Service (NHS) data in England, which also indicated that overall, there was a reduction in the amount of radiotherapy delivered. "Radiotherapy is a very important treatment option for cancer, and our study shows that across the English NHS,...
This improvement in technology helped to change the concept of radiotherapy, from palliation of advanced prostate cancer to a curative approach for localised disease [2]. Fundamental to this therapeutic philosophy was the need to deliver an adequate dose to eradicate the tumour whilst avoiding ...
Cancer immunotherapy has transformed traditional treatments, with immune checkpoint blockade being particularly prominent. However, immunotherapy has minimal benefit for patients in most types of cancer and is largely ineffective in some cancers (such as