This immunological cascade specifically generates activated T cells able to induce immunogenic cell death directed against cancer cells bearing those antigens. By its ability to overcome some tumour immune escape mechanisms, radiation provides a non-pharmacological and cost-effective approach to potentially...
T cells are the main component of lymphocytes and play an essential part in the immune response through cellular contacts or the killer cytokines’ secretion, serving as the body’s fighters against disease, infection and tumor formation. The roles of T cells in the TME and CIT are multiple [...
Immunogenic and non-immunogenic cell death in the tumor microenvironment. Adv. Exp. Med. Biol. 1036, 65–79 (2017). Article CAS PubMed Google Scholar Formenti, S. C. & Demaria, S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J. Natl Cancer Inst. 105, 256–265 (...
Doxorubicin (DOX), a widely used systemic chemotherapy drug, which induced so-called “immunogenic cell death (ICD)” process, stimulating anti-tumor immune responses and increasing antigen-specific T cells activation, proliferation, and infiltration (Fig. 2a; Node 3) [145]. The Mesoporous silica...
SBRT also induced the expression of TAAs such as CA9, MUC1, 5T4 and NY-ESO1 and elevated the TP53 DNA damage response, which triggered immunogenic cell death (ICD) characterized by the release of HMGB1 and HSP70 [20, 117]. In addition, the supernatant of hypofractionated irradiated tumor ...
Radiotherapy alters the immune composition of the tumor and influences upregulation of MHC I and cancer-testis antigens, inducing immunogenic cell death and supporting dendritic cell activation. Paradoxically, it also increases the relative ratio of regulatory T cells to CD4+ cells, which hampers an...
RT can promote a special functional type of cell apoptosis named immunogenic cell death (ICD) [80,81,82] and can stimulate antigen-specific, adaptive immunity by some undetermined mechanisms [83]. ICD leads to subsequent anti-tumor immune responses including the release of tumor antigens by irra...
and radiotherapy efficacy. (A) Microbiota modulates the immune response in radiotherapy: This section focuses on the ability of the microbiome to increase lymphocyte infiltration into tumors, leading to immunogenic cell death during radiotherapy. Additionally, it highlights the combined effect of bacterial...
Radiotherapy and immunogenic cell death. Semin. Radiat. Oncol. 25, 11–17 (2015). PubMed Google Scholar Brown, J. M., Carlson, D. J. & Brenner, D. J. The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int. J. Radiat. Oncol. Biol. Phys. 88, 254–262...
Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy Radiation therapy (RT) can induce immunogenic cell death and elicit anti-tumor immune responses. Here the authors report the design and characterization of a risedronate-manganese-based nanosystem...