T cells are the main component of lymphocytes and play an essential part in the immune response through cellular contacts or the killer cytokines’ secretion, serving as the body’s fighters against disease, in
Radiation therapy (RT) can induce immunogenic cell death and elicit anti-tumor immune responses. Here the authors report the design and characterization of a risedronate-manganese-based nanosystem for in situ vaccination, amplifying RT-mediated anti-tumor immunity in preclinical models. Zhusheng Huang...
T cells are the main component of lymphocytes and play an essential part in the immune response through cellular contacts or the killer cytokines’ secretion, serving as the body’s fighters against disease, infection and tumor formation. The roles of T cells in the TME and CIT are multiple [...
With a high-Z element, MGTe could enhance radiosensitivity by reactive oxygen species (ROS) production and cancer cell immunogenic death (ICD) under X-ray irradiation, which would also trigger antitumor immune. At meanwhile, TM and BM would further enlarge the immunological effects through antigen...
Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death Oncoimmunology, 3 (2014), p. e28518, 10.4161/onci.28518 View in ScopusGoogle Scholar [12] R.R. Weichselbaum, H. Ishwaran, T. Yoon, et al. An interferon-related gene signature for DNA damage resistance is a pred...
Doxorubicin (DOX), a widely used systemic chemotherapy drug, which induced so-called “immunogenic cell death (ICD)” process, stimulating anti-tumor immune responses and increasing antigen-specific T cells activation, proliferation, and infiltration (Fig. 2a; Node 3) [145]. The Mesoporous silica...
Doxorubicin (DOX), a widely used systemic chemotherapy drug, which induced so-called “immunogenic cell death (ICD)” process, stimulating anti-tumor immune responses and increasing antigen-specific T cells activation, proliferation, and infiltration (Fig.2a; Node 3) [145]. The Mesoporous silica ...
“This work has started to close that gap, but it also highlights the need for deeper interrogation of factors such as dose fractionation, the timing of radiotherapy and volumes irradiated so that we can optimise radiation-induced immunogenic cell death.” ...
Radiotherapy and immunogenic cell death. Semin. Radiat. Oncol. 25, 11–17 (2015). PubMed Google Scholar Brown, J. M., Carlson, D. J. & Brenner, D. J. The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int. J. Radiat. Oncol. Biol. Phys. 88, 254–262...
Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress. Nat. Commun. 12, 145 (2021). Article CAS PubMed PubMed Central Google Scholar Min, Y. et al. Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy....