Combining radionuclide therapy with radiotherapy - ScienceDirectRaghava Kashyap KarriRodney J Hicks
Targeted radionuclide therapy, in which radiopharmaceuticals deliver potent radionuclides to tumours for localized irradiation, has addressed unmet clinical needs and improved outcomes for patients with cancer1,2,3,4. A therapeutic radiopharmaceutical must achieve both sustainable tumour targeting and fast cle...
However, radiotherapy is a complex procedure and requires the patients to make a number of hospital visits to complete a full course of treatment (Unak, 2002; Perkins, 2007). X-rays were the first ...DeNardo SJ, Denardo GL. Targeted radionuclide therapy for solid tumors: An overview. ...
Radiolabeled somatostatin analogue therapy, or PRRT, is a targeted form of systemic radiotherapy that helps to deliver radionuclides directly to tumors that express somatostatin receptors. PRRT has demonstrated its efficacy among patients with inoperable or metastatic NETs. The radionuclide177Lu-Dotatate bin...
NM600 TRT. Furthermore, given18F-FDG PET/CT is presently used to monitor responses to chemotherapy and radiation in NHL, but only indirectly measures tumor cell metabolism and not truly anti-cancer therapy specific killing, usage of86Y-NM600 to more specifically predict responses to90Y-NM600 ...
Kidney dosimetry after peptide receptor radionuclide therapy using 177Lu-labelled somatostatin analogues is a procedure with multiple steps. We present the SPECT/CT-based implementation at Aarhus University Hospital and evaluate the uncertainty of the various steps in order to estimate the total uncertaint...
The main challenge for systemic radiation therapy using radiopharmaceuticals (SRT) is to optimise the dose delivered to the tumour, while minimising normal tissue irradiation. Dosimetry could help to increase therapy response and decrease toxicity after SRT by individual treatment planning. Peptide receptor...
governed by invariable nuclide-specific decay rates. Vast amounts of energy could be unleashed from nuclear reactions. The emitted radiation interacting with matter offered possibilities for powerful nuclear measurement techniques, as well as medical applications in imaging, diagnostics, and therapy. The ...
Even in the setting of responsive, immunologically “hot” tumors, radiotherapy may enhance the depth or durability of response by priming more effective adaptive anti-tumor immunity. Consequently, it is plausible that focal radiation therapy may become a critical component of systemic therapy for the...
Interestingly, no additional survival benefit was demonstrated in those patients who had a PR vs SD radiologically post therapy (Figure 1). Similarly, there was no statistically significant survival benefit between patients who reported a PR or SD clinically post therapy Table 3. Probability of ...