放射性核素偶联药物(Radionuclide Drug Conjugates, RDC)-2 核素 接着上篇,说说RDC的关键部分-核素(Radionuclide)这个部分会涉及无机化学的一些基础知识,这里默认大部分会读这篇的读者有高中化学基础的。需要的话,可以参考系列-1的元素周期表,会适当加些图片和例子说明来让这部分没那么枯燥。 核素和同位素 (Nuclidevs....
核药也叫做放射性核素偶联药物 (Radionuclide Drug Conjugates RDC),随着放射性化学、核医学、分子生物学技术的发展和多学科交叉融合,放射性药品已经成为全球药品研发的热门领域,目前主要用于肿瘤治疗方向。 核素肿瘤药物的巨大发展潜力也得到各大医药公司的重视,除了Curium、CardinalHealth等核药主力企业外,诺华、拜耳、强生...
Radionuclide drug conjugates (RDCs) can be classified in terms of the form of targeting molecules as antibody targeted radionuclide antibody conjugates (RACs), and small molecule based (including peptides) radionuclide drug conjugates. RDC, as an innovative drug conjugate form, has many similarities f...
therapeuticimmunoconjugatesOver the last decade, Antibody Drug Conjugates (ADCs) have gained a great success due to their documented clinical efficacy and manageable toxicity. Generally the word "drug" is associated with a chemotherapeutic drug, however "drug" can also be associated withother cytotoxic...
When the engineered radiopharmaceutical binds to the tumour-specific protein, the system undergoes a binding-to-ligation transition and readily conjugates to the tyrosine residues through the ‘click’ SuFEx reaction. The application of this strategy to a fibroblast activation protein (FAP) inhibitor (...
(ATLL)1,2. Therefore, novel therapeutic strategies/combinations are urgently needed for patients with T-cell NHLs. Immunoconjugates including monoclonal antibodies (mAb) and mAb-drug conjugates targeting CD30, CD52, CD4, and chemokine receptor 4 (CCR4); histone deacetylase (HDAC) inhibitors; ...
In this review we will give an overview of the recent preclinical research projects regarding PCa TRT using PSMA-specific radiotracers, with special emphasis on small molecule PSMA inhibitors. Figure 1 summarizes the preclinical approaches discussed in this review. Figure 1. Schematic overview of precl...
Use of Lipiodol as a drug-delivery system for transcatheter arterial chemoembolization of hepatocellular carcinoma: A review. Crit. Rev. Oncol. Hematol. 2013, 88, 530–549. [Google Scholar] [CrossRef] Lepareur, N.; Ardisson, V.; Noiret, N.; Garin, E. 188Re-SSS/Lipiodol: Development ...
通过大手笔的并购交易,诺华国际企业为自身构建了全球核药龙头坚实的护城墙,其获批不到一年的靶向放射性配体疗法Pluvicto销售峰值有望超20亿美元。另外,德国生命科学企业拜耳、放射性药物公司POINT Biopharma、生物技术公司Telix、全球最大的医用放射性同位素生产企业之一ITM均在积极布局核药赛道。
Evaluating (225)Ac and (177)Lu radioimmunoconjugates against antibody-drug conjugates for small-cell lung cancer. Mol Pharm. 2020;17:4270–9. https://doi.org/10.1021/acs.molpharmaceut.0c00703. Article CAS PubMed Google Scholar Ballal S, Yadav MP, Bal C, Sahoo RK, Tripathi M. ...