This chapter summarizes the present clinical aspects of chemo- and/or radiation therapy and LNM in GI cancers from a limited number of studies. Neoadjuvant therapy may reduce LNM in patients with esophageal cancer, and LNM has an equal negative impact on prognosis as in node-positive patients. ...
A combination of cytotoxic chemotherapy and radiation therapy (chemoradiotherapy, CRT) is still the standard treatment regimen for patients with solid tumors of advanced or metastatic stage. The primary objectives of radiation treatment are to achieve local and regional tumor control and to minimize norm...
Newer biologic drugs and immunomodulatory agents, as well as more tolerated and effective radiation therapy schemes, have reduced treatment toxicity in oncology patients. However, although imaging assessment of tumor response is adapting to atypical responses like tumor flare, expected changes and complicat...
Cancer therapy may not be directly responsible for the development of poor-prognosis therapy-relatedacute myeloid leukemia(t-AML) ormyelodysplastic syndrome(t-MDS), new research suggests. Conventional clinical wisdom holds that chemotherapy and radiation induce genome-wide DNA damage that in a small pe...
Similar to CAR-NK cell therapy, CAR-M therapy has recently emerged as a novel approach, and relevant studies are currently in the early stages. Such therapy may overcome two main limitations of CAR-T cell therapy: immune cell infiltration and an immunosuppressive TME. Encouragingly, macrophages ...
Hormone therapy, also called hormone treatment or hormonal therapy, which treats cancers that use hormones to grow (such asbreast cancerandprostate cancer). Stem cell transplants. Doctors use chemo or radiation to destroy as many cancer cells as possible, then try to replace them with healthy st...
Minesh Mehta, MD, deputy director, chief, Radiation Oncology, Miami Cancer Institute, Baptist Health, discusses recent advancements in in radiation therapy for patients with prostate cancer, particularly noting the benefits and significance of lutetium Lu 177 vipivotide tetraxetan (Pluvicto; formerly 17...
The management of brain metastases (BM), the major cause of cancer morbidity and mortality, is becoming an emerging area of interest. Surgery, whole brain radiation therapy (WBRT), or stereotactic radiosurgery (SRS), have historically been the main focal
“Security dilemma”: active immunotherapy before versus after radiation therapy alone or chemo-radiotherapy for newly diagnosed glioblastomaAuthor links open overlay panelAlexandrina S. Nikova 1, Georgios Sioutas 2, Michael Karanikas 2, Theodossios Birbilis 2...
chemo-radiation regimen. With sCRT the tumor grows back after chemo- and radiotherapy, as the cell kill was not dense enough and allowed the tumor to re-grow. Since the tumor cell number was reduced to below 1 (high probability of tumor control) with Concurrent chemo-radiation therapy, the...