Brain stem tumorRadiotherapyComputed tomographySeventy-nine patients with tumors of the medulla oblongata, pons, and midbrain treated by radiation therapy between 1962 and 1987 were analyzed. According to histology obtained in 28 cases, 61% were high-grade astrocytomas and 39% were low-grade ...
Recent progress in targeted systemic therapies for solid tumors has contributed to significantly increased survival times for patients with metastatic disease. However, this progress has been accompanied by a higher incidence of brain metastases (BM), with an estimated 10-40% of primary cancers develop...
S. et al. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan Detroit cancer surveillance system. J. Clin. Oncol. 22, 2865–2872 (2004). Article PubMed Google Scholar Davies, M. A. Targeted therapy for brain metastases. Adv. Pharmacol. 65, ...
Radiation therapy (RT) is a critical treatment modality for both primary and metastatic brain tumors, yet ∼30% of patients experience cognitive decline post-RT. This cognitive toxicity is linked to low radiation doses affecting the hippocampal dentate gyrus. Hippocampal avoidance-whole brain RT co...
Radiation Therapyor Radiotherapy is the delivery of high intensity X-rays, generally used in the treatment of cancers and brain disorders. There are many ways to haveradiation therapy, but they all work in a similar way. Carefully controlled high-energyX-rayskill or damagecancercells. This stops...
Dinh J, Stoker J, Georges RH, Sahoo N, Zhu XR, Rath S, et al. Comparison of proton therapy techniques for treatment of the whole brain as a component of craniospinal radiation. Radiat Oncol [Internet]. 2013;8:289.https://doi.org/10.1186/1748-717X-8-289. ...
Stereotactic Radiation Therapy / Stereotactic Radiosurgery A non-invasive treatment that delivers tightly focused radiation beams from multiple directions to converge at the tumour site, primarily small targets within the brain and spine, exposing surrounding healthy tissue to much smaller doses of radiatio...
Comparing intelligence quotient change after treatment with proton versus photon radiation therapy for pediatric brain tumors. J Clin Oncol. 2016;34:1043–9. https://doi.org/10.1200/JCO.2015.62.1383. Article CAS PubMed PubMed Central Google Scholar Kayama T, Sato S, Sakurada K, Mizusawa J, ...
During radiation therapy, image-guidance aims at locating the tumour target and tailoring the volume target to anatomical and tumoral variations. Imaging systems are now integrated with conventional accelerators, and newer accelerators have techniques allowing tumour tracking during the irradiation. More ...
therapy; however, autophagy is also critical for optimal immune function, and mediates cell-extrinsic homeostatic effects owing to its central role in danger signalling by neoplastic cells responding to immunogenic chemotherapy and/or radiation therapy. In this Perspective, we discuss accumulating ...