In rodent safety/toxicity studies, the toxicity dose (TD50), of MnTnHex-2-PyP5+ was determined to be 12.5 mg/kg [9]. That dose causes shivers and hypotonia which is, in part, due to the blood pressure drop. Given its efficacy at a very low 0.05 mg/kg dose, MnTnHex-2-PyP5+ ...