The role of mast cell infiltrates in the pathology of radiation damage to the lung has been a subject of continuing investigation over the past four decade... JD Down,M Medhora,IL Jackson,... - 《Radiation Research》 被引量: 15发表: 2013年 Association between absolute volumes of lung spare...
This damage typically classified in early and late radiation toxicity could oscillate between asymptomatic and severe manifestations. Three common grading systems have used to stratify the severity of symptoms (see Table 1) [8]. In almost 40% of cases, conventional RT irradiates a considerable ...
Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reactive oxygen species, which harm nucleic acids, lipids, and proteins. While cancer cells are mo...
Damage to one or several components of an organ may result in a variety of clinical symptoms that may have different physiological bases. Conventional models are frequently inadequate because they ignore functional and structural heterogeneities. By better understanding these heterogeneities we may be ...
Bone marrow (hematopoietic syndrome)—This syndrome is caused by damage to stem cells in the bone marrow resulting in a reduction in cell lines. Symptoms include bleeding and infection (low platelets and leukocytes). Usually occurs after exposure to between 0.7 and 10 Gy (70– 1,000 rads). ...
Besides very high radiation doses above 50 Gy, which are irrelevant to human experience, there are no symptoms or clinical signs in the first 6 months after irradiation. This is the so called latent period of RN. First clinical damage becomes apparent in the acute phase [6–18 months] ...
The biological link between radiographic changes and radiation response is not fully understood. It is likely though that early changes in HU during the radiation pneumonitis phase are dominated by a local inflammatory response and damage to microvascular endothelial cells leading to vessel leakiness35....
In a rat model exposed to different doses of X-rays, within a few hours of irradiation the lungs became hyperpermeable due to damage to type II pneumocytes and developed increased surfactant production visible on electron microscopy, which would predispose to the risk of pneumonitis [13]. 4. ...
The elevated levels of IL-6, TNF-α, and C-reaction protein (CRP) have caused more lungs damages. There is currently no treatment for long-term symptoms caused by a SARS-CoV-2 infection. This could be the next major issue to address. Veronese et al. (2022) found olfactory dysfunction ...
Radiation therapy treatscancerby using high-energy waves to kill tumor cells. The goal is to destroy or damage the cancer without hurting too many healthy cells.It is given over a certain time period; it can be given around the time of surgery or chemotherapy. It can also be used to ease...