The median progression-free survival (PFS) was 11.0 months with everolimus compared with 4.6 months with placebo (HR = 0.35). However, Strosberg notes, the RADIANT-3 trial was designed as a crossover study that allowed patients randomized to placebo to receive everolimus following progression. As...
Everolimus, an inhibitor of the mammalian target of rapamycin, has recently demonstrated efficacy and safety in a Phase III, double-blind, randomized trial (RADIANT-3) in 410 patients with low- or intermediate-grade advanced pancreatic neuroendocrine tumours. Everolimus 10 mg/day provided a 2.4-fol...
Everolimus, an inhibitor of the mammalian target of rapamycin, has recently demonstrated efficacy and safety in a Phase III, double-blind, randomized trial (RADIANT-3) in 410 patients with low- or intermediate-grade advanced pancreatic neuroendocrine tumours. Everolimus 10 mg/day provided a 2.4-...
Everolimus, an oral mTOR inhibitor, has shown promising antitumor activity in 2 phase II studies, leading to further investigation in the largest phase III randomized controlled trial completed in pNET patients. Methods: Patients with advanced low- or intermediate-grade pNET were randomly assigned ...
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Strosberg JR, Lincy J, Winkler RE, et al. Everolimus in patients with advanced pancreatic neuroendocrine tumors (pNET): Updated results of a randomized, double-blind, placebo-controlled, multicenter, phase III trial (RADIANT-3). J Clin Oncol 2011; 29(Suppl.):4009....
Updated Survival and Safety Data From RADIANT-3-a Randomized, Double-blind, Placebo-controlled, Multicenter, Phase III Trial of Everolimus in Patients With Advanced Pancreatic Neuroendocrine Tumours (pNET)SunitinibDocetaxelNSCLCSequence treatmentColorectal cancer (CRC) is the third most common malignancy ...