radial glia‐like cellIn the adult mouse hippocampus, new neurons are produced by radial glia﹍ike (RGL) neural stem cells in the subgranular zone, which extend their apical processes toward the molecular layer, and express the astrocyte marker glial fibrillary acidic protein, but not the ...
We describe a “reactivation” of the quintessential behavior of neural stem cells, mitotic somal translocation (MST) in glioblastoma. As this phenomenon is not known to occur outside of development, targeting MST may present a novel therapeutic strategy to cripple oRG-like GSCs. Additionally, char...
The modified radial glia appear to be neural progenitor cells belonging to the astroglial lineage (type B cells) assuring both stem cell self-renewal and production of a differentiated progeny in the adult subventricular zone, and also playing regulatory roles in stem cell niche maintenance....
Human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NSCs) hold promise for treating neurodegenerative and demyelinating disorders. However, comprehensive studies on their identity and safety remain limited. In this study, we demonstrate that hiPSC-NSCs adopt a radial glia-asso...
Further, we identify niche-specific regulatory programs for RG-like cells, and functionally confirm that FAM20C mediates invasive growth of RG-like cells in a neuron-rich microenvironment in a human neural stem cell derived orthotopic DMG model. Together, our results provide a blueprint for ...
3) radial glial cells 放射状胶质细胞 1. The changes of PEBP mRNA after the induced activation of hippocampal radial glial cells in vitro 海马放射状胶质细胞体外诱导激活后的PEBP mRNA表达变化 2. Radial glial cells function as scaffolding and neural stem cells 放射状胶质细胞的研究进展 更多例句...
Ohtsuka T., Sakamoto M., Guillemot F., and Kageyama R. (2001) Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developping brain.J. Biol. Chem.276, 30,467–30,474. CASGoogle Scholar ...
SOX2 cells are decreased in the oSVZ in the DS brain SOX2 is a neural stem progenitor cell marker (expressed in neural progenitors and populations of intermediate progenitors) and is highly expressed in radial glia cells [21,24,40,43,48,56]. From mid-gestation (15–24 GW), in both eupl...
Radial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differentiate from neuroepithelial cells (NCs) with stem cell properties. We show that the morphogen Fgf10 is transiently expressed by NCs coincident with the transition period of NC differentiation into RG. Targeted...
We discuss how these approaches, together with an ability to expand radial glia-like neural stem (NS) cell lines, may offer unique opportunities in basic and applied neurobiology. 展开 关键词: Radial glia Neural stem cells In vitro cell culture Embryonic stem cells EGF and FGF-2 Neurogenesis ...