RAD51放射敏感性肿瘤DNA双链断裂同源重组HepG-2细胞放疗和化疗是肿瘤治疗的重要手段,然而很多肿瘤的放疗,化疗敏感性与正常组织相差不大,治疗效果并不理想.迄今为止,国际上尚未找到公认的高效低毒的放疗,化疗增敏剂,这已经成为肿瘤研究的一个热点和难点.近年的研究发现,DNA双链断裂(double-strand breaks,DSB)修复效率,...
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[结论](1)采用离心加贴壁法培养滇南小耳猪BMSCs是一种高效扩增的方法.(2)第二代滇南小耳猪BMSCs纯度高,可作为组织工程种子细胞.(3)第二代滇南小耳猪BMSCs有多分化潜能,且能向软骨分化,适合作软骨组织工程种子细胞. 第二部分rAd5-BMP2-EGFP和rAd5-TGFβ3载体的构建 [目的]构建rAd5-BMP2-EGFP和rAd5-...
Convert radians to degrees.Jan Graffelman (jan.graffelmanupc.edu)
Direct disassembly of repair complexes has been demonstrated for the Srs2 protein, which translocates along DNA and can strip away bound protein. This activity is proposed to maintain stringent conditions for initiation of the recombinational repair pathways. Disassembly of repair complexes by the Rad...
From structural studies, Ubc13-Mms2 facilitates free chain synthesis primarily by positioning of the K63 residue of the acceptor Ub in the active site of Ubc 13.;Together with the Rad5 Ub ligase (E3), Ubc13-Mms2 assists in the polyubiquitination of PCNA in vivo to promote error-free ...
Rad1-Rad10 is a structure specific endonuclease that cleaves the 3'non-homologous tails (3'NHT). Msh2-Msh3 binds and stabilizes the 3'NHTs while also interacting with Rad1-Rad10. Saw1 was recently identified in a genetic screen and was determined to interact with Rad1-Rad10 and Msh2-...