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To further develop the FociRad model for γ-H2AX assessment in different blood cell populations, one could modify the model by staining with other specific surface markers (e.g. T cell – CD3, B cell – CD19, NK cell – CD56, monocyte – CD14, granulocyte – CD15). Finally, FociRad ...
The arrow indicates the position of normal pGL3-control vectors and M indicates the markers. The expression levels of HSF4 mutations and truncations were also detected by western-blot. 3.2. HSF4 cataract mutations fail to repair the spontaneous DNA damage To determine if HSF4 cataract-causative ...
for 48 h. β-actin was used as a loading control. Concentration-dependent cellular damage in response to PF-477736 treatment in MDA-MB-231 cells (E) and Hs578T cells (F). Cleaved polymerase (PARP) and γ-H2AX were used as markers of apoptosis and DNA damage. β-actin was used as ...