This is partly due to limited knowledge of the molecular mechanisms that injured germ cells elicit to repair damage and survive or to abort repair and activate biochemical pathways leading to death. So far, we know that following spontaneously occurring or drug-induced DNA damage, the efficiency ...
刚才后面。 2个小时后面驱动。 [translate] ai ce bnrw [translate] aLuckily, we don't have to choose between an examined life and death. But the sad thing is, most people avoid leading an examined life. It's not that they don't have time or make time. They actively avoid examining ...
Double-stranded DNA breaks (DSBs) are toxic DNA lesions that can lead to cell death or genomic alterations if left unrepaired. Cells have evolved multiple DNA repair mechanisms to deal with DNA breaks1,2. In G1 phase of the cell cycle, DNA breaks are predominantly repaired through non-homolo...
As most of the knowledge on polη regulation comes from analysis of its canonical function at ultraviolet damage, it is not yet clear if this new lesion-independent function shares the same regulatory mechanisms. Here, we show that, unexpectedly, polη travels with replication forks during ...
More importantly, to the best of our knowledge, no longitudinal study has thus far examined the link between polymorphisms in DSB repair and the risk of death. This longitudinal study thus analyzes whether four common polymorphisms (rs2155209, rs7963551, rs17105278, rs2735383) in four selected ...
These are linked tan renga (short linked) poems, and I am so in awe of Grant’s great all-round knowledge and erudition. I never knew what kind of link would happen as it could come from his Science, Math, literature, or poetry (and more) background. The idea of the tan renga is...
Preferred terms used for deaths were: disease progression (n = 3), neoplasm progression (n = 1), sepsis (n = 1), cardiac death (n = 1; patient died prematurely at Day 9 due to heart attack; patient had cardiovascular comorbidities and obesity), malignant neoplasm progression (n = 2),...
According to Global Cancer Statistics 2020, prostate cancer (PCa) is a common cancer type that causes death worldwide in men. Approximately 1.4 million people are diagnosed with PCa worldwide, resulting in 375,000 deaths annually, which is an upward trend compared to 2018 [1,2]. The androgen...
However, given the unique nature of most reported pathogenic variants, we foresee that reference laboratories performing RAD51C screening should be prepared to have readily available resources and knowledge to conduct and interpret RAD51C functional tests. ACKNOWLEDGEMENTS We particularly want to ...
Moreover, these methods do not require prior knowledge of the genome sequence27. Our group has previously used the original RAD-Seq and ddRAD-Seq methods to analyse citrus28,29,30, loquat31, and firefly32. The four lineages are well known, and Zanthoxylum piperitum is cultivated all over ...