Reported herein is the concept of fluorous racemic mixture synthesis (FRMS), which is applied to two types of proof-of-concept experiments. Mixtures of racemic O -benzoylmandelate derivatives and prochiral crotonamide derivatives, respectively, bearing different lengths of fluorous-cleavable tags are ...
It is worth noting that the intensities of various diffraction peaks in the copolymer sample from racemic catalyst are obviously lower than the stereocomplexed PCXC obtained from the 1:1 mixture of the opposite enantiomers (Fig. 3, bottom, plots B and C). In addition, the melting endothermic...
The present application further discloses certain pyrrolol[2,3-d]pyrimidine compounds having the 3R,4R stereochemical configuration shown above. Corresponding pharmaceutical compositions and methods for the treatment or prevention of a disorder or condition selected from organ transplant rejection, xeno ...
An improved process is described to resolve a racemic mixture in any proportion of 5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy benzene sulfonamide as a free base or some o
and thus a decrease in corresponding counterclockwise platelet density in homochiral vaterite helicoids (Fig.3). Whenl-Asp is equal tod-Asp in the balanced racemic condition, the disorganized, heterochiral mixing of Asp enantiomers dominates and no effective homochiral assembly domain is formed on ...
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding a mixture of the aliphatic carboxylic acid to the material formed by: (i) forming a solution comprising said racemic mixture ...
The crystalline stereocomplexed polycarbonates can be prepared by mixing enantiopure polymers with opposite configuration, which derived from the asymmetric copolymerization with CO2 using enantiopure catalyst or/and chiral epoxides. Herein, we develop a
Finally, we successfully prepared the chiral precursor of (R)-(–)-2-fluoroibuprofen by the present kinetic resolution using (–)-BTM as shown in Scheme 2, and hydrolysis of the formed ester produced the desired (R)-(–)-2-fluoroibuprofen (87% ee) ([α]D27 −26.9° (c 1.2, EtOH...
container of known mass and then transferred to the cold room to be combined by grinding via a mortar and a pestle. After the transfer of each monocomponent powder, the weighing containers were then weighed at room temperature in order to calculate the exact molar ratio for each mixture ...