wherein R'' has the same meaning as R and R' represents a C1-C8 alkyl group or a benzyl group, in the presence of an enzyme, preferably a lipase capable of hydrolyzing selectively (asymmetrically) isomer (R) of ester (II), leaving unaltered isomer (S), whereafter the usual separation ...
The process is continuously carried out by forming an aqueous super Saturated Solution of the racemate, seeding with seed crystals of the desired isomer of the enantiomorphic, L or D-form optically active isomer, allowing the seeded Solution to flow in one direction without causing back flow ...