Esketamine, the S (+) enantiomer of ketamine, is the most widely used form in the anesthetic environment in some countries, and new studies have shown that it may also be effective in depression and with better tolerability. However, no study so far has directly compared esketamine with ...
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The aim of this study is to assess the efficacy and safety of esketamine compared to ketamine in patients with treatment-resistant depression (TRD).METHODS:This is a randomized, double-blind, active-controlled, bicentre, non-inferiority clinical trial, with two parallel groups. Participants were ...
EsketamineKetamineDepressive disorderMajorBipolar disorderDepressionRandomized controlled trialsMeta-analysisBackground Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear. ...
Racemic ketamine also led to significantly lower SI scores than placebo or midazolam (SMD = -0.36, 95% CI -0.71 to -0.01, P =0.04). The evidence for the treatment of SI with esketamine was inconsistent. The pooled effect sizes for long-term anti-SI effects did not reveal significant ...
EsketamineKetamineDepressive disorderMajorBipolar disorderDepressionRandomized controlled trialsMeta-analysisBackground: Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear. ...
Wilkowska, AlinaDepartment of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCubaa, Wiesaw JerzyDepartment of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandSpringer Berlin HeidelbergEuropean Archives of Psychiatry and Clinical Neuroscience...
Seventeen healthy volunteers were treated with 0.5 μg.kg–1.min–1 SNP or placebo during a 3-h infusion of escalating doses of racemic ketamine (total dose 140 mg) or esketamine (70 mg). Pain pressure threshold (PPT) and arterial blood samples for measurement of S- and R-ketamine and...
Letter to the editor - Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysisBreno Souza-Marques a bRodrigo P. Mello a bAna Paula Jesus-Nunes a bFernanda S. Correia-Melo a b cAline S. Sampaio a b d...
Letter to the Editor: Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysisdoi:10.1016/j.jad.2021.04.024Joakim EkstrandJournal of Affective Disorders