Serum concentrations of nefiracetam reached maximum values (Cmax) within 2 h for all dosage groups, and declined monophasically after Cmax with half-lives of 3–5 h. The area under the concentration-time curve (ALTC∞) and Cmax were linearly related to the dose. The apparent clearance (...
吸收 Seletracetam is rapidly absorbed following oral administration, reaching the Cmax within 1 hour and displaying oral bioavailability of >90%. 分布量 The volume of distribution is approximately 0.6 L/kg, which is close to that of total body water. 蛋白结合 Demonstrates low plasma protein ...
Briefly, an sgRNA targeted to exon 3 of Rac1 was complexed with a recombinant Cas9 protein and transfected into the cells using Lipofectamine CRISPRMAX (CMAX00001, Thermo Fisher Scientific). 2 days post-transfection, cells were seeded for single-cell clonal expansion. Rac1 KO was confirmed by ...
·袋-1)和参比制剂消旋卡多曲颗粒的主要药动学参数:Tmax分别为(1.8±1.2),(1.9±1.3)和(0.7±0.2)h,t1/2分别为(1.4±0.4),(1.2±0.7)和(1.1±0.8)h,Cmax分别为(802.0±356.5),(804.2±459.8)和(845.6±285.8)ng·mL-1,AUC0-8分别为(1 617.0±532.6),(1 628.9±672.1)和(1 621.0±532.2...