The present invention relates to recombinant raccoon poxvirus vectors that express the rabies virus glycoprotein gene at the hemagglutinin (ha) locus of the poxvirus genome or express the glycoprotein gene of the same or different rabies strains at the thymidine kinase (tk) and the hemagglutinin (ha...
First, the glycoprotein binds to the cellular receptor to enter target cells to initiate the virus infection process. The acidic environment of the endosome induces a conformational change in the glycoprotein from the bent hairpin conformation to an elongated structure, resulting in the fusion of the...
The design of structure-based competitive peptides that interfere with virus-host PPIs with significant roles in the viral life cycle, could be a promising therapeutic strategy to combat viral infections [[19], [20], [21]]. The rational knowledge about viral proteins and host partners helps ...
Rabies is a lethal disease caused by the rabies virus (RABV), which causes acute neurological infections in mammals, including human beings. We previously reported that an mRNA vaccine (LVRNA001) encoding the rabies virus’s glycoprotein induced strong p
Such virus spillover from one host species to another can and has led to viral evolution and adaptation in a new host species over broad timescales. Bat lyssavirus variants, for example, sporadically spill over to infect wild and domestic animals. New host species, such as red foxes on ...