First, the glycoprotein binds to the cellular receptor to enter target cells to initiate the virus infection process. The acidic environment of the endosome induces a conformational change in the glycoprotein f
The present invention relates to recombinant raccoon poxvirus vectors that express the rabies virus glycoprotein gene at the hemagglutinin (ha) locus of the poxvirus genome or express the glycoprotein gene of the same or different rabies strains at the thymidine kinase (tk) and the hemagglutinin (ha...
The design of structure-based competitive peptides that interfere with virus-host PPIs with significant roles in the viral life cycle, could be a promising therapeutic strategy to combat viral infections [[19], [20], [21]]. The rational knowledge about viral proteins and host partners helps ...
Rabies is a lethal disease caused by the rabies virus (RABV), which causes acute neurological infections in mammals, including human beings. We previously reported that an mRNA vaccine (LVRNA001) encoding the rabies virus’s glycoprotein induced strong p
The RABVG ectodomain is a homotrimer, and trimers are often called spikes. They are responsible for the attachment of the virus through the interaction with nicotinic acetylcholine receptors, neura...
FIG. 8 presents the predicted amino acid sequence of synthetic codon-optimized rabies virus glycoprotein G (SEQ ID NO:1); FIG. 9 is a schematic cloning diagram of donor plasmid p397-cOX40L; FIG. 10 is a schematic representation of genomic organization of vCP3015, carrying classic Rabies vir...
Molecular Brain (2022) 15:13 https://doi.org/10.1186/s13041-022-00898-8 METHODOLOGY Open Access Brain‑wide TVA compensation allows rabies virus to retrograde target cell‑type‑specific projection neurons Zengpeng Han1,2,3,4†, Nengsong Luo1,3,4,5†, Jiaxin Kou1,6, ...
(C) Structure imaging of AAV labeled neurons in all layers with AAV2/9-hsyn-DIO-EGFP virus injected into AuC in Ntsr1-Cre transgenic mice on day 21. (D) Relative gray value of CVS and AAV labeled structure along the dashed line in (B) and (C). (E) Boxplots showing the comparison...