Black, MD (Chicago Department of Public Health); Maria Paz Carlos, PhD (Maryland Department of Health and Mental Hygiene); William C. Carson, BS (CDC); Gabrielle Clodomir, BS (University of Georgia); John Davies-Cole, PhD, MPH (DC Department of Health); James A. Ellison, BS (CDC); ...
Currently, the rabies virus vaccine strains are CTN, 3aG, PV and Flury in Fujian province, and veterinary vaccine strains are ERA and SAD. Since G protein is the major inducer of protective immunity against rabies [37], we cannot link our findings with the rabies vaccination in Fujian ...
The mice were inocu- lated in the hind limb with rabies vaccine (Sanofi-PASTEUR SA, France). In addition, human rabies immunoglobulin (HRIG, Taibang Health, Taian, China) at 20 IU/kg and Fab091 (treated with 32, 20, 8, 2, and 0.5 IU/kg) were administered on d 0. The mice ...
The mouse group treated with both vaccine and human rabies immunoglobulin (HRIG)/Fab091 (32 IU/kg) showed protection against rabies, compared with the control group (P<0.05, Logrank test). Conclusion: The antibody fragment Fab was shown to be a neutralizing antibody against RABVG. It can ...
The RABVGgene encodes a transmembrane glycoprotein containing an ectodomain that protrudes from the viral membrane and is responsible for binding to cellular receptors, mediating viral entry into host cells. RABV G is also the target of both the rabies vaccine and the HRIG component of PEP [47]...
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little is known regarding the optimal immunization protocol needed to protect small ruminants. To find an optimal vaccination strategy, we tested the effect of one and two doses of vaccine on sheep and goats. Initially, animals were vaccinated with one dose, and half of them received a second...
and forestry workers—overlap with some professions at a higher risk of exposure to tick bites and tick-borne pathogen infections. We hypothesized that individuals identified by the public health system as at risk of rabies virus infection, and consequently vaccinated against rabies virus, also share...
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The health of the experimental animals was monitored for 18 months without any signs of clinical disease demonstrating that the prototype vaccine was generally safe. A new procedure for immunizing injured people, called the “Alivisatos ether method”, included the application of a total of 10 g ...