Such viruses could form the basis of future vaccines for rabies (reviewed by Hicks et al[41]) and one variant has been trialled as an oral vaccine for wildlife[42]. The method of attenuation falls into two categories. The first are those constructs that have a gene deletion, usually the...
Additionally, the lengthy campaign time lowered population immunity through high population turnover and the short life of the vaccine that was used [9, 10]. In late 2010, a local non-governmental organization (NGO), the Bali Animal Welfare Association (BAWA), togethe...
We have a cat that had not been vaccinated for rabies in years. He was always an indoor cat. Well, recently he's started going outside. Suddenly, we can't keep him indoors for anything, but I still had not taken him for the vaccine yet. He has done strange stuff lately like growl...
results suggest possible multiple introductions of rabies into the Middle East, and regular trans-boundary movement of disease. Although 4000 years have passed since the original description of disease consistent with rabies, animals and humans are still dying of this preventable and neglected zoonosis....
Animal studies have demonstrated that rabies-specific antibodies, especially the neutralizing antibodies, played an essential role in vaccine-mediated protection6. Yet, clinical evaluation of rabies vaccines in humans is not possible due to ethical considerations. Therefore, new rabies vaccines or rabies-...
“There was no experimental evidence for his published claims about the extent of the safety and efficacy of the vaccine in animals before the human rabies trial,” said Geison.” “Pasteur’s message for contemporary science, Geison argued,was to puncture the “hopelessly misleading” image of ...
Fig. 4. Predicted results from OLS regressions of the number of dogs vaccinated by hour, for (A) all vaccination strategies combined, (B) mobile static point (MSP), (C), MSP + capture vaccinate release (CVR), and (D) door-to-door vaccination (DDV) and oral rabies vaccine (ORV)...
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Bakker AB, Python C, Kissling CJ, Pandya P, Marissen WE, Brink MF et al (2008) First administration to humans of a monoclonal antibody cocktail against rabies virus: safety, tolerability, and neutralizing activity. Vaccine 26(47):5922–5927 Article CAS PubMed Google Scholar Bakker KM, Rocke...
Nagarajan T, Rupprecht CE, Dessain SK et al (2008) Human monoclonal antibody and vaccine approaches to prevent human rabies. In: Dessain SK (ed) Human antibody therapeutics for viral disease. Current topics in microbiology and immunology, vol 317. Springer, Berlin, Heidelberg. https://doi.org...