The RABVGgene encodes a transmembrane glycoprotein containing an ectodomain that protrudes from the viral membrane and is responsible for binding to cellular receptors, mediating viral entry into host cells. RABV G is also the target of both the rabies vaccine and the HRIG component of PEP [47]...
In addition, no astrocyte infection has been detected after infection with lab-attenuated or vaccine strains [122]. Abundant expression of the RABV P-protein, a major IFN antagonist of RABV in astrocytes [115,149,150,151,152,153,154], suggests that inhibition or delay of innate immune ...