Rabiesvaccinationfor prevention and PET was introduced in the nineteenth century, first by Galtier and later by Pasteur.91 While the control of animal rabies is central to the prevention of human disease, only a few nations have succeeded in eliminating rabies, and these maintain quarantine procedu...
In addition to vaccination, postexposure prophylaxis includes human rabies immunoglobulin, 20 IU/kg, administered as soon as possible after the exposure, up to 7 days after the first dose of vaccine. As much of the dose as possible should be administered at the bite wound site, and any ...
J. Esposito et al., “Successful oral rabies vaccination of raccoon poxvirus recombinants expressing rabies virus glycoprotein” Virology 165: 313-316 (1988); J. J. Esposito, “Live poxvirus-vectored vaccines in wildlife immunization programmes: the rabies paradigm. Res. Virol. 140: 480-482 (...
This is the purpose of vaccination - exposing the animal to a safe form of rabies so that its immune cells will create protective antibodies. One would expect, therefore, that the level of rabies antibodies in the animal's blood could be used in the diagnosis of rabies infection. If the ...
antigenic determinants carried on the G-protein vary substantially among the rabies virus strains. Virus-neutralizing antibodies raised by vaccination with inactivated virus are directed against G. While it is clear that T cell responses to G, N, and NS, participate in immune responses to the viru...
Among those given initial treatment, the vaccination regimens were not completed because of a short incubation period and the onset of symptoms within two weeks of bites on the head and neck region. All epidemiological features of the human rabies cases in Bali resemble those reported elsewhere. ...
Vaccination combined with anti-rabies virus neutralizing antibodies is essential for postexposure prophylaxis for category III exposure to the rabies virus. In this review, we discussed the neutralizing epitopes of the rabies virus and the neutralization mechanism of monoclonal antibodies. The neutralizing...
Despite the existence of effective vaccination, rabies is still a public health concern [2]. Unfortunately, there is no cure once clinical rabies develops mainly due to failure to receive valid post-exposure prophylaxis [3] so that about 59,000 human deaths are reported annually in the world ...
FIG. 4. B cell responses to AdC68rab.gp vaccination. Mice were vaccinated orally or intramuscularly with 108 pfu of AdC68rab.gp vector. Tissues were harvested 2 and 4 weeks later, and lymphocytes were isolated and tested for rabies virus-specific B cells in an ELISpot assay. (A) Mean ...
Although vaccination and immune globulin can prevent the development of rabies after exposure, there are no effective drugs to treat rabies [4]. The high mortality rate of rabies poses a serious threat to human health and public safety [5]. Therefore, it is of great importance to study the ...