Open sesame--treating rabies in the brainDavid Ojcius
A usually fatal viral disease of warm-blooded animals that causes inflammation of the brain and spinal cord. It is transmitted by the bite of an infected animal and can be prevented in humans by a vaccine. See Note athydrophobia. The American Heritage® Student Science Dictionary, Second Edit...
Rabies causes acute inflammation of the brain, producing psychosis and violent aggression. The virus, which paralyzes the body's internal organs, is always deadly for those unable to obtain vaccines in time. Some 55,000 people die from rabies every year. For the first time, Tel Aviv Universit...
For example: electrical messages move from nerve cells located in the brain, down an axon to the spinal cord. Chemical messages cross from the end of that 'brain-derived' axon to the nerve cell of the target spinal cord nerve (whose own axon and nerve-ending supplies the muscles that the...
“We knew that nicotinic acetylcholine receptors, which bind to the virus in muscles, are also found in the brain, and we presumed that [the] virus could also bind to such receptors,” says Dr. Hueffer. “If snake venom has a similar structure to parts of the virus, and inhibits these...
To assist in making recommendations for sampling of brains for the fluorescent antibody test (FAT), a study was conducted to determine the regions of the brain where rabies antigen is found most reliably. Each identifiable part of 252 rabies-positive brains of various species was re-tested using...
Role of Virus-induced Neuropeptides in the Brain in the Pathogenesis of Rabies Rabies virus (RABV) infection is characterized by the rapid neuronal spread of RABV into the CNS before a protective immune response is raised. Therefore, ... E Weihe,M Bette,MAR Preuss,... - 《Developments in ...
From the bite or other area of penetration, the virus multiplies as it spreads along nerves that travel away from the spinal cord and brain (efferent nerves) and into the salivary glands. The rabies virus may lie dormant in the body for several weeks or months, but rarely much longer, bef...
Rabies is a preventable viral disease most often transmitted through the bite of a rabid animal. The rabies virus infects the central nervous system of mammals, ultimately causing disease in the brain and death. The vast majority of rabies cases reported to the Centers for Disease Control and ...
in its genome and express the antigen in the infected cell. According to the selected virus used as vector, they could be replicative or nonreplicative since they produce or not the viral progeny in the vaccinated organism, respectively. In addition, these viral-vectored vaccines are safe and ...