Open sesame--treating rabies in the brainDavid Ojcius
From the bite or other area of penetration, the virus multiplies as it spreads along nerves that travel away from the spinal cord and brain (efferent nerves) and into the salivary glands. The rabies virus may lie dormant in the body for several weeks or months, but rarely much longer, bef...
Rabies is a zoonotic disease caused by a highly neurotropic RNA virus typically present in the saliva of a rabid animal. Transmission is commonly through a bite wound. Once saliva enters the body, virions infect peripheral nerves and travel to the spinal cord and brain, resulting in acute, ...
A usually fatal viral disease of warm-blooded animals that causes inflammation of the brain and spinal cord. It is transmitted by the bite of an infected animal and can be prevented in humans by a vaccine. See Note athydrophobia. The American Heritage® Student Science Dictionary, Second Edit...
Evaluation of efficacy of anti-rabies virus drug (small molecular weight compound) against lethal rabies virus infection in a BALB/c mouse modelMice Short-term and one-year duration of immunity field efficacy of the killed rabies vaccine (Defensor 3), against USDA rabies challenge virus (New Yor...
The rabies virus replicates in muscle tissue and then gradually travels via the nervous system until it finally reaches the brain. Here it continues to replicate further and travels to infect the cornea of the eye and salivary glands, which is how the virus comes to be present in saliva and...
Registerorlog in, in order to read the full article. Pathophysiology Rabies virusbinds theAChreceptorofperipheral nervesin the bite wound → migratesretrogradelyalong the axonalmicrotubules(using motor proteindynein) → enters theCNS→ infects the brain ...
Evaluation of six commercially available rapid immunochromatographic tests for the diagnosis of rabies in brain material. PLoS Negl Trop Dis. 2016;10:e0004776. https://doi.org/10.1371/journal.pntd.0004776. Article PubMed PubMed Central Google Scholar FAO and GARC. Developing a stepwise ...
Rabiesviruscausesanacuteencephalitis(inflammationofthebrain)inallwarm-bloodedhosts.Rabiesisnot,inthenaturalsense,adiseaseofhumans.Theimpactofrabiesonpublichealthincludesanestimateoftheanimalpopulationthatisaffectedandthestepsinvolvedinpreventingtransmissionofrabiesfromanimalstohumans.Raccoons,skunks,foxes,coyotes,and...
Pets get rabies by getting bitten by, or coming into contact with the saliva of, an infected animal. Rabies is seen more often in certain wildlife species including bats, raccoons, skunk and foxes.1 Once the rabies virus enters the body, it travels along the nerves to the brain and attack...