The activity of both Rab5 and Rab11 was required for sustained activity of Erk1/2 and nuclear CREB phosphorylation, and increased transcription of a BDNF-dependent program of gene expression containing CRE binding sites, which includes activity-regulated genes such as Arc...
Taken together, these results suggest that the context within which a CXXX sequence occurs may also critically control the modification of a protein by prenylation, and that the Rab5 and Rab11 carboxyl termini do not possess conventional CXXX sequences. Instead, their CCXX and CCXXX motifs may...
Invitrogen Anti-RAB5 Recombinant Monoclonal (0K5J1), Catalog # MA5-35161. Tested in Western Blot (WB) and ELISA (ELISA) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (0.71 mg/mL).
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RBL cells (1.5 × 107 cells/ml) were transiently transfected with control pSilencer vector or with shRNAs directed against Rab5A and Rab5BC, as previously described29. Forty-eight hours later, total RNA was purified using the PerfectPure RNA purification system (5 Prime) according to the...
抗体是一类能与抗原特异性结合的免疫球蛋白。抗体按其反应形式分为凝集素、沉降素、抗毒素、溶解素、调理素、中和抗体、补体结合抗体等。按抗体产生的来源分为正常抗体(天然抗体),如血型ABO型中的抗A和抗B的抗体,和免疫抗体如抗微生物的抗体。按反应抗原的来源分为异种抗体,异嗜性抗体,同种抗体和自身抗体。按抗...
Significance:Thesefindingsshowthatendosomal/lysosomalRAB5andRAB7,whichregulatemitophagy,areessentialforthesurvivalofcoloncancerstemcells. 鉴于癌症干细胞(CSC)在耐药性和复发中的关键作用,靶向CSC在癌症治疗中仍然具有前景。在这里,我们显示参与内溶酶体途径的RAB5/7通过调节线粒体途径在维持CSC存活中起关键作用。
Long-distance axonal trafficking plays a critical role in neuronal function and transport defects have been linked to neurodegenerative disorders. Various lines of evidence suggest that the small GTPase Rab5 plays a role in neuronal signaling via early e
Rab5 regulates intracellular membrane trafficking of several pathogens, including Salmonella enterica serovar Typhimurium [7]-[9], Mycobacterium spp [10], and Listeria monocytogenes[11]. Rab5 may also mediate internalization of P. gingivalis in host cells; however, little is known about the role ...