. The renewed R-loopDB pro-vides updates, improvements and new options, in-cluding access to recent experimental data. It in-cludes genome-scale prediction of RLFSs for hu-mans, six other animals and yeast. Using the ex-tended quantitative model of RLFSs (QmRLFS), wesignif i cantly inc...
Jenjaroenpun P, Wongsurawat T, Sutheeworapong S, Kuznetsov VA. R- loopDB: a database for R-loop forming sequences (RLFS) and R-loops. Nucleic Acids Res. 2017;45:D119-d127.Jenjaroenpun, P., Wongsurawat, T., Sutheeworapong, S. & Kuznetsov, V. A. R-loopDB: a database for ...
R-loop在转录过程中形成的三链核酸结构,计划外的R-loop会干扰DNA复制和转录,并与多种疾病状态中双链断裂、基因组不稳定、衰老和细胞死亡等有关。人类细胞中存在抑制R-loop形成的因素,比如解旋酶SETX能够等解开R-loop的杂交环区域,另外乳腺癌易感基因BRCA1也参与到R-...
相比于传统的全基因组测序,R-loop高通量脱靶检测省时省力,经济实惠,可用于规模化的评估和筛选。 1 R-loop脱靶检测实验原理 利用CBE作用于单链DNA的特性,通过nSaCas9在编辑靶点外的基因组区段诱导R-loop,从而人为制造单链DNA(ssDNA)区域,可放大CBE...
R-loop: an emerging regulator of chromatin dynamics: Table 1. The dynamic structure of chromatin, which exists in two conformational states: heterochromatin and euchromatin, alters the accessibility of the DNA to regu... Q Al-Hadid,Y Yang - 《Acta Biochimica Et Biophysica Sinica》 被引量: 6...
R-loop是一种RNA/DNA三链结构体,与基因组稳定性和转录调控有关。 通过电镜观察,R-loop大小在150~500bp之间。 硫酸氢盐测序(bisulfate sequencing)表明R-loop主要出现在基因启动子的下游。 R-loop所在非模板链(又称编码链)具有很强的序列偏好性,计算方式为(G-C)/(G+C) ...
A closed loop transcutaneous power transfer system for implantable devices with enhanced stability This paper describes a closed-loop wireless inductive power transfer system for an implantable retinal prosthetic device. The proposed system is designed t... GWG Wang,WLW Liu,R Bashirullah,... - ...
A timing loop occurs when a clock traces its own clock signals. The following methods can be used to prevent timing loops. Set the SSM quality level of a line clock used as a clock source to DNU. This prevents timing loops that may occur on the peer device because a clock source whose...
Loopback Detection缺省配置 配置自动模式的Loopback Detection 配置手工模式的Loopback Detection 使能手工模式的Loopback Detection功能 (可选)配置检测报文的发送周期 配置手工模式的Loopback Detection处理动作 (可选)配置受控接口的恢复时间 检查手工模式Loopback Detection的配置结果 Loopback Detection配置举例 ...
One-loop contributions in the effective field theory for the AN rarr; NN transition.One-loop contributions in the effective field theory for the AN rarr; NN transition.doi:10.1103/PhysRevC.87.044614We consider the AN → NN weak transition, responsible for a large fraction of the nonmesonic ...