R‐CHOP and RB showed similar activity and efficacy, but with different safety profiles and long‐term events, suggesting that the treating physician should carefully select the most appropriate chemotherapy regimen for each patient based on patient's individual characteristics, choices, and ...
and were treated with the R-CHOP chemotherapy protocol (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone). The protocol included 6 to 8 cycles of the chemotherapy treatment. The medians and ranges of the clinical parameters and comparison data are summarized in Table 2. We di...
CHOP-R therapy overcomes the adverse prognostic influence of BCL-2 expression in diffuse large B-cell lymphoma. BCL-2 protein expression correlates with shorter survival in patients with diffuse large B cell lymphoma (DLBCL) who are treated with CHOP chemotherapy. We... KS Wilson,LH Sehn,B Ber...
The clinical research protocol was approved by our Institutional Review Board (IRB). R-CHOP chemotherapy was administered as follows: one course of chemotherapy consisted of an intravenous infusion of cyclophosphamide 750 mg/m2, adriamycin 50 mg/m2, vincristine 2 mg, and oral administration ...
英文标题:Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL 期刊:《Cancer Cell》 发表时间:2021年12月13日 研究领域:DLBCL 联合化疗 DOI号:10.1016/j.ccell.2021.10.006 文献概述 在DLBCL中,属于ABC但不是GCB的亚型肿瘤活性需要依赖于慢活B细胞受体信号通路,而伊布替尼可以靶向该信号通...
Richter transformation (RT) is an aggressive lymphoma occurring in patients with chronic lymphocytic leukaemia. Here we investigated the anti-CD3/anti-CD19 T-cell-engager blinatumomab after R-CHOP (i.e. rituximab, cyclophosphamide, doxorubicin, vincristi
Gemcitabine is active in lymphoma.Methods: We performed a randomized phase II trial of the addition of gemcitabine to standard CHOP chemotherapy with or without rituximab [(R)CHOP]. The trial was also designed to determine the maximal tolerated dose (MTD) of gemcitabine in this combination. ...
(NHL).Methods:TwentypatientswithrelapsedorrefractorB-cellNHLaftermedicationoftraditionalchemotherapyacceptedR-GEMOXregimen,theefficacytoxicitieswasevaluatedafteratleast4cyclesofchemotherapy,thetoxicitieswasevaluatedafteratleast1cyclesofchemotherapy.Results:Ofthe20cases,7patientswereincompleteremissionand8inpartialremission,...
primary central nervous system lymphoma or secondary involvement; chemotherapy or other investigational therapy within 28 days prior to start of cycle 1; significant cardiovascular or liver disease that could affect compliance with the protocol or interpretation of results or that could increase risk to ...
Perforations of the stomach and small intestine are rare but life-threatening complications of the R-CHOP immunochemotherapy. We present two patients with DLBCL, who were treated with R-CHOP regimen. Both had perforation of the small intestine shortly after first cycle. One of them underwent ...