DFT PBE/3ζ study of relative stability of the R - and S -isomers of α-alanine in open carbon nanotubes with chirality indices (5,5), P,M-(5,1) and P,M-(5,2) has shown that the encapsulated molecule of the amino acid notably changes its geometrical and electronic characteristics....
The nicotine metabolite cotinine (1-methyl-5-[3-pyridynl]-2-pyrrolidinone), like its precursor, has been found to exhibit procognitive and neuroprotective effects in some model systems; however, the mechanism of these effects is unknown. In this study, both the R-(+) and S-(-) isomers ...
S -isomer pharmacokinetic parameters determined in this study were C max of 10.1μg/ml by IM injection, C 0 of 13.4 μg/ml by IV injection, AUC of 44.7 or 69.4μg*hr/ml by IM or IV injection, respectively, and T of 2.8 or 3.6hr by IM or IV injection, respectively. Total ...
A high-performance liquid chromatographic technique for the separation of the optical isomers of salsolinol is described. The simple and rapid method allows the direct resolution of the enantiomers without derivatization. A complete separation (baseline resolution) of (R)-(+)-salsolinol and (S)-(-...
A mixture of (R)- and (S)-2-(4-alkanoylphenoxy)- or (R)- and (S)-2-(4-aroylphenoxy)propionic esters I ##STR1## with an enantiomeric excess of at least 90% is prepared by reacting a mixture of (R) and
A DIFFERENCE IN PHARMACOLOGICAL ACTION OF R (+) AND S (-) ISOMERS OF BEFUNOLOL, BETA-ADRENOCEPTOR BLOCKER A DIFFERENCE IN PHARMACOLOGICAL ACTION OF R (+) AND S (-) ISOMERS OF BEFUNOLOL, BETA-ADRENOCEPTOR BLOCKER TAKAYANAGI Issei , KOIKE Katsuo Journal of pharma... TAKAYANAGI,Issei,KOIKE,...
hydroxy, C.sub.1-4 alkoxy, carboxy, esterified carboxy or in vivo hydrolyzable acyloxy; and the pharmaceutically acceptable salts, individual isomers, mixtures of isomers, processes for preparation, compositions, and methods of use thereof... J Berger,Robin D. Clark,Richard M. Eglen,... 被引...
So, we need an extra piece of information to distinguish enantiomers (and other stereoisomers) by their names properly addressing the stereochemistry as well. Cahn, Ingold,andPrelogdeveloped a system that, regardless of the direction we are looking at the molecule, will always give the same name...
1.9 Isomers Smiles CC1=CC=C(C=C1)S(=O)(=O)O.C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](NCCO2)C3=CC=C(C=C3)F2. Properties2.1 Appearance solid 2.2 StorageTemp Inert atmosphere,2-8°C3. Use and Manufacturing3.1...
1.9 Isomers Smiles C[C@H](C1CC1)N2. Properties2.1 Storage Air Sensitive. Ambient temperatures. 2.2 pKa 10.87±0.29(Predicted) 2.3 Water Solubility Miscible with water.3. Safety and Handling3.1 Safety RIDADR: UN2735 HazardClass: 8 PackingGroup: III 3.2 Sensitive Air Sensitive 3.3 Specificat...