R and M Squid Box 5200 Puffs Disposable pod Kit feature a whopping 5200 puffs and 12ml capacity, this pre-filled and pre-charged device offers an impressive 5% (50mg) salt nicotine content, ensuring a satisfying and smooth draw every time. 4.75...
2013. Nicotine biosynthesis, metabolism and translocation in tobacco as determined by nicotine demethylase mutants. Phytochemistry 95, 188-196.Cai, B.; Jack, A.M.; Lewis, R.S.; Dewey, R.E.; Bush, L.P. (R)-nicotine biosynthesis, metabolism and translocation in tobacco as determined by ...
We found that R-MOD is more potent and effective than S-MOD in attenuating nicotine self-administration in Long–Evans rats. As Long–Evans rats did not show a robust reinstatement response to nicotine, we used alcohol-preferring rats (P-rats) that display much higher reinstatement responses ...
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The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on...
Alvin,V,Terry,Patrick,M,Callahan,Daniel,Bertrand 摘要: The nicotine metabolite cotinine (1-methyl-5-[3-pyridynl]-2-pyrrolidinone), like its precursor, has been found to exhibit procognitive and neuroprotective effects in some model systems; however, the mechanism of these effects is unknown. ...
Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as mea- sured by a progressive-ratio schedule in rats. Eur J Pharmacol. 2007;559:173–9. 9. Xi ZX, Gilbert JG, Pak AC, Ashby CR Jr., Heidbreder CA, Gardner EL. Selective ...
NicotineAbuseDopamineReinforcementα6β2* nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic neurons mediate nicotine-evoked dopamine (DA) release and nicotine reinforcement. α6β2* antagonists inhibit these effects of...doi:10.1007/s11064-015-1680-4...
S Mexal,M Frank,R Berger,CE Adams,RG Ross,R Freedman,S Leonard 摘要: Nicotine is known to induce the release of multiple neurotransmitters, including glutamate and dopamine, through activation of nicotinic receptors. Gene expression in the N-methyl-d-aspartate postsynaptic density (NMDA-PSD), ...
… Exhaled breathcondensatefrom theRTube™ and filters were extracted for gas-chromatograph/mass spectrometer (GC/MS) analysis. The concentrations of nicotine, propylene glycol, … An Exhaled microRNA Panel Interrogated for Lung Cancer Case-Control Discrimination ...