Succinate:quinoneoxidoreductases(SQORs; EC 1.3.5.1) areenzymesthat couple the two-electronoxidationof succinate to fumarate (Eq.1) to the two-electron reduction of quinone to quinol (Eq.2). (1)Succinate⇄fumarate+2H++2e− (2)Quinone+2H++2e−⇄quinol ...
Quinone oxidoreductases of the plasma membrane relate functionally to the operation of a cell surface redox chain, where cytosolic NAD(P)H is oxidized. Plasma membrane quinones serve as lipid-soluble transmembrane shuttles to transfer the 2H + + 2e - from NAD(P)H to 1/2 O 2 to form ...
The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response elements pathway enables cells to survive oxidative stress conditions through regulating the expression of cytoprotective enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1). Th...
Type II NADH:quinone oxidoreductases (NDH-2s) are membrane proteins involved in respiratory chains. These proteins contribute indirectly to the establishment of the transmembrane difference of electrochemical potential by catalyzing the reduction of quinone by oxidation of NAD(P)H. NDH-2s are widespre...
Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an antimicrobial drug target or used as a substitute for dysfunctional respiratory complex I in neurom
Quinones are known to have a high protein affinity [146], which means they can be separated by precipitating proteins from extract matrices [147]. The quinones are then recovered or separated from the protein-quinone complex through methods such as fractionation, centrifugal filtration and chromatofo...
On the basis of the spectroscopic characterization of heterologously produced SdhE from Sulfolobus tokodaii, the protein was proposed in a previous study to contain a labile [2Fe–2S] cluster ligated by cysteine residues of the CCG domains. Using UV/vis, electron paramagnetic resonance (EPR), 57...
2. Prevent and treat the liver damage Can significantly reduce serum bilirubin, alanine aminotransferase levels, make liver function normal, regulate liver damage and have very good curative effect on liver disease. 3. Reduce free radical damage to human body...
In this review, we examine the key events during the evolution of this oxidoreductase family from an Mbh-like ancestor to Complex I. We hypothesize that the diversification of this Mbh-like ancestor to Complex I was driven by the increased energy yields associated with coupling of Fd oxidation...
5.3.4 NADPH:quinone oxidoreductase 1 and adipocyte differentiation NADPH:quinone oxidoreductase 1 (NQO1) may generate quinones, quinoneimines, and azodyes, accompanied by inhibition of ROS generation [263]. NQO1 protein is present in human adipocytes and the NQO1 mRNA level is higher in adipocyte...