Methods We studied the pharmacokinetics of quinine in eight normal subjects and eight patients with chronic renal failure on haemodialysis after a single oral dose of quinine sulphate (300mg). Results The concentration of 伪 1 -acid glycoprotein (AAG), the major binding protein for quinine, was ...
Quinine sulphate tablets (Quinoc®300 mg) were kindly supplied by Douglas Pharmaceutical, Auckland, New Zealand. Subjects remained fasting for 3 h after drug administration.Venous blood samples were collected into heparinized tubes before the dose, and at 0.25,0.5,0.75,1,1.5,2,2.5,3,4,6,8,...
10 mg/kg10 (10)8 hourlyOralFor 7 Days (As Quinine Sulphate) High Risk Groups Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and Geriatrics. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them an...
169 mg equals 100 mg base. ? Quinine sulphate (dihydrate). 121 mg equals 100 mg base. View all description Quinine, an alkaloid derived from the bark of the cinchona tree, is a blood schizontocidal agent that is more toxic than chloroquine.Quinine is used to treat malaria caused by ...
It is important to avoid confusion arising from calculation of the dose of quinine depending on its various salts. The following doses are equivalent: quinine base 100 mg; quinine sulphate 121 mg; quinine bisulphate 169 mg; and quinine dihydrochloride 122 mg. The dose of quinine sulfat...
Three months earlier she had complained of leg cramps and had been prescribed quinine sulphate 300 mg as necessary. One dose had been used with good effect at that time. Two days before admission she had suffered dysuria and frequency of micturition but had received no antibiotic therapy. Leg ...
He took quinine sulphate 300 mg OD for leg cramps. His past medical and drug history was otherwise unremarkable. Peribulbar anaesthesia was given uneventfully. During phacoemulsification and removal of the final quadrant of the lens nucleus, the eye became tense, the red reflex reduced, and an ...
A 39-year-old female patient presented to our A + E Department 12 h after taking an overdose of quinine sulphate (300 mg tablets x 28).She complained of blurred vision and nausea. Blood pressure was 105/55 mmHg, pulse 144 min~(-1), ECG showed sinus-tachycardia. Intravenous fluids, ...
The purpose of this study is to compare the bioavailability (BA) of a new quinine suppository made from theobroma oil to that of an existing tablet formulation in healthy volunteers. Methods: Six healthy volunteers were administered with 300 mg of QN sulphate as suppository and tablet in a ...