Substituted amino - quinazolinone, drugs containing said compounds, methods for their use and manufactureAs for this invention general system 1< Conversion 1 >(In formula, the basis R - R and A is defined like the range of the bill and patent claim)Substitution amino - kinazorinon and the ...
Hence, there is a need to use radioprotective drugs to protect organs at risk. This is because high-energy radiation is necessary for ion-beam radiotherapy, and the possible risk of high linear energy transfer radiation in the surrounding normal tissue may be of more general concern, even ...
1-Methyl-4(1H)-quinazolinone is used as a building block for the synthesis of bioactive compounds, particularly in the development of new drugs and agrochemicals. Its unique structure and properties contribute to its versatility in creating potential therapeutic agents. ...
1 Futhermore, numerous clinical drugs consist of the quinazolinone core (Fig. 1), including Mecloqualone2 which was famous for its useful insomnia resistant effect, Nolatrexed3 as a thymidylate synthase inhibitor for the treatment of cancer and Cloroqualone4 which was used for cancer as well....
Inhibition of Pgp is also required so that, Pgp transport function cannot limit the penetration of drugs in tissues [51]. Cytochrome P450 (CPY) also plays an essential role in eliminating drugs during metabolic transformations. There are five isoforms (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A...
Curr. Pharm. Design (2006)M.E. Duggan et al. Expert Opin. Ther. Pat. (2000) J.W. Tamkun et al. Cell (1986) S.A. Mousa et al. Drugs Future (1996) J.J. Marugan et al. J. Med. Chem. (2005) There are more references available in the full text version of this article. ...
H. Anderson, Jr.--Handbook of Hypertension, Clinical Pharmacology of Antihypertensive Drugs, ed. A. E. Doyle, Vol. 5, pp. 246-271, Elsevier Science Publisher, Amsterdam, The Netherlands, 1984]. Recently, several non-peptide compounds have been described as A II antagonists. Illustrative of...
In this patent, Bristol-Myers Squibb presents a new class of NNRTIs obtained using efavirenz as the lead molecule, which also seem to be effective against HIV isolates resistant to the three clinically used drugs belonging to this class of pharmacological agents. Efavirenz is not only highly ...
administration; the route of administration; and the rate of excretion; the duration of the treatment; any drugs used in combination or coincidental with the specific compound employed; and other such factors well known in the medical arts. These factors are discussed in Goodman and Gilman's “...
A carotid artery is annulated for measuring arterial blood pressure and drugs are administered intravenously. Heart rate (HR) is monitored by a cardiotachometer. Renal vascular resistance (RVR) is calculated as the ratio cf mean arterial blood pressure (MABP)/renal artery blood flow (RBF). ...