Sles1 suppressive function is shared between the NZW and 129/SvJ alleles, which is interesting since both strains carry strong lupus susceptibility loci which are functional on a B6 background (i.e., in the absence of the suppressor loci), but not in the parental strains (Bygrave et al.,...
The plasma membrane of eukaryotic cells is asymmetric with respect to its phospholipid composition. Analysis of the lipid composition of the outer leaflet is important for understanding cell membrane biology in health and disease. Here, a method based on
Quantitative image analysis techniques have gained an undeniable role in several fields of research during the last decade. In the field of biological wastewater treatment (WWT) processes, several computer applications have been developed for monitoring microbial entities, either as individual cells or in...
After decades of research, one question remains: Are these cofactors triggering PrPSc conversion and/or propagation? Single- or double-stranded NAs, PolyA, tRNA, mRNA, small RNA, and antisense oligonucleotides (ASOs) were shown to convert PrP to aggregated, amyloid, PK-resistant forms [31–33]...
Cobb, P., & Steffe, L. (2011). Part I Radical constructivism: Chapter 3: The constructivist researcher as teacher and model builder. In E. Yackel, K. Gravemeijer, & Anna Sfard (Eds.),A journey in mathematics education research: Insights from the work of Paul Cobb(pp. 19–32). Dordr...
and in scientific research (e.g., cell tracking8,9, controlling plasma in tokamak10). To date, most deep learning-based computer vision applications to the materials science domain are mainly focused on relatively simple tasks like classification11,12, object detection13,14,15, and semantic segm...
generation of novel multicomponent crys- tals with improved physical properties.[5–7] There is a growing need to understand the time-dependence of these processes, and A. A. L. Michalchuk, Dr. I. A. Tumanov, Prof. E. V. Boldyreva ascertain control over their temporal...
Research articleDefining a quantitative framework for evaluation and optimisation of the environmental impacts of mega-event projects Author links open overlay panelOlga Parkes a, Paola Lettieri a, I. David L. Bogle bShow more Add to Mendeley Share Cite...
automatic gain control (AGC) boosting ratio iBASIL ion injection time (IT) single-cell proteomics Cell and tissue heterogeneity is an important fundamental issue in many research areas (e.g. developmental and cancer biology (1)), but the resulting variation is lost in conventional “bulk” omics...
applications, namely samples with high matrix content and most quantitative analysis, typically require sample preparation ranging from simple dilution to extensive multi-step procedures. ᅟ The authors thank the German Research Foundation (DFG) for financial support (grant EN-927/1-1) and the ...