With the advent of new biomarkers and cognitive tools, new neuroscience technologies such as functional dynamic connectivity and the identification of subtle clinical features; it is now possible to detect early stages at risk or prodromes of a first psychotic episode. Current concepts reconceptualize...
effector T-cell types to predict clinical efficacy and safety of immunotherapy drugs and identify biomarkers of interest15,20,21. However, as of yet there have been no modeling studies performed to predict the complexities of the dose–response relationship for trispecific antibodies. Our QSP model...
healthy individuals with G2019S mutation in theLRRK2gene (non-manifesting carrier/NMC), PD individuals without G2019S mutation (idiopathic PD/iPD), and PD individuals with G2019S mutation (LRRK2 PD), we applied a proteomics strategy to determine potential diagnostic biomarkers for PD from urin...
Systems pharmacologySystems modelsQuantitativeMathematical models of drug action are essential in contemporary drug discovery and development. Applications include exposure-response modeling (pharmacokinetics-pharmacodynamics or PK-PD); quantitative understanding of biological target and pathway; and systems ...
Possible explanations include the lack of quantitative and validated biomarkers, the subjective nature of many clinical endpoints, and complex pharmacokinetic/pharmacodynamic relationships, but also the possibility that highly selective drugs in the CNS do not reflect the complex interactions of different ...
The present study was designed to reveal the potential targets and mechanism of action for QFOL by exploring its influence on the host cellular network following RSV infection. We investigated the serum proteomic changes and potential biomarkers in an RSV-infected mouse pneumonia model treated with ...
Mechanistic modeling of tau biomarkers for amyloid load. A Quantitative Systems Pharmacology study of amyloid‐tau interaction doi:10.1002/alz.073896Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationGeerts, HugoBergeler, SilkeWalker, MikeVan der Graaf, Piet...
Multiple sclerosis (MS) is a common neurological disease in North America and Europe. Although most patients develop major locomotor disability over the co... D,H,Miller,... - 《Clinical Pharmacology & Therapeutics》 被引量: 27发表: 2012年 Quantitative label-free multimodality nonlinear optical ...
2018, Angewandte Chemie - International Edition Personalized proteomics: The future of precision medicine 2016, Proteomes The Cellular Thermal Shift Assay: A Novel Biophysical Assay for in Situ Drug Target Engagement and Mechanistic Biomarker Studies 2016, Annual Review of Pharmacology and Toxicology Vie...
If a component is not classified as Generally Regarded as Safe or has not had toxicology or pharmacology studies under current Good Laboratory Practices (cGLP), then an extensive amount of preclinical testing is required before clinical testing can occur47. Each of PAtrace's components either has ...