The incidence of QTc prolongation (QTc > 470 ms in males, QTc > 480 ms in females, or >20 ms increase in QTc from baseline) was 24%. Three patients developed significant QTc prolongation (QTc >500 ms or >60 ms increase in QTc from baseline). No patients discont...
QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics The finding of about one-quarter of the patients with borderline or prolonged QTc intervals could indicate mandatory ECG recordings in this population. This... E Johnsen,K Aanesen,...
Moxifloxacin can be used as a positive control for QT/QTc studies in Japanese subjects; and topiroxostat may not cause QT-interval prolongation in males as well as females. 展开 关键词: topiroxostat moxifloxacin QT QTc study ICH E14 Japanese ...
Participants in the first sex-specific QTc quartile (males; ≤369 ms, females;≤384 ms) had a lower waist-to-hip ratio, a lower HbA1C level, and were more likely to smoke than participants in the highest sex-specific QTC quartile. Association of prolongation of the QTc interval and the ...
3 Definitions of QTc prolongation vary, but often this condition is described as a QTc interval of >440 ms.2 Other definitions allow for a higher cutoff, such as 460 ms, in females.3 Mechanism The QT interval represents the summation of cardiac action potentials.2 Drug-induced QT ...
Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure. The role of QTc interval prolongation in heart failure remains poorly defined. To better understand it, we analyzed the QTc interval duration in patients w... Vrtove...
Prolongation of the QT interval usually results from delayed repolarisation. This can be caused by drugs or inherited ion channel abnormalities, which block or result in loss of function of potassium channels (IKr, IKs, and IKl), or opening or gain of function of sodium (Ina) or calcium ...
There was a significant difference in QTc interval between living and deceased pts with QTc of 452.5 msec (430–477) vs. 469(433.5–538.25) msec (p=0.017). Conclusions: Prolongation of QTc is common among adults with SCD and is associated with other cardiac abnormalities that are directly ...
Congenital long QT syndrome (LQTS) affects an estimated 1 in 2500 people and typically presents with syncope, seizures or sudden death. Whereas someone exhibiting marked prolongation of the QT interval with QTc exceeding 500 ms who was just externally defibrillated from torsades de pointes while ...
Prolongation of the SVR latency was found in the children with ADHD versus the controls, but the difference was statistically insignificant. The present ... N Vaney,Y Anjana,F Khaliq - 《Functional Neurology》 被引量: 9发表: 2011年 加载更多来源...